FB2024_03 , released June 25, 2024
Allele: Dmel\fhUAS.cRa
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General Information
Symbol
Dmel\fhUAS.cRa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Runko
FlyBase ID
FBal0239759
Feature type
allele
Associated gene
Dmel\fh
Associated Insertion(s)
Carried in Construct
P{UAS-fh.R}
Key Links
Transgenic product class
wild_type
(Runko et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Runko et al., 2008)
Mutagen
in vitro construct
(Runko et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-fh.R}
Cytology
Description

UAS regulatory sequences drive expression of the full length fh precursor protein.

(Runko et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
fh
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      DOES NOT model  Friedreich ataxia 1
      CEA
      (Runko et al., 2008)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Females expressing fhScer\UAS.cRa under the control of Scer\GAL4Act5C show increased resistance to oxidative stress (either 20mM paraquat or 1% H[[2]]O[[2]]) compared to controls.

      Females expressing fhScer\UAS.cRa under the control of Scer\GAL4Act5C show increased resistance to toxic iron levels (12.5mM FeCl[[3]]) compared to controls.

      Females expressing fhScer\UAS.cRa under the control of Scer\GAL4Act5C have a normal food ingestion rate.

      Females expressing fhScer\UAS.cRa under the control of Scer\GAL4Act5C have a 35% increase in median lifespan and a 28% increase in maximum lifespan compared to controls.

      (Runko et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      fhScer\UAS.cRa
      fhUAS.cRa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Runko
      Secondary FlyBase IDs
        References (1)