FlyBase Allele Report: Dmel\Hipk[3]

General Information

Symbol

Dmel\Hipk³

Species

D. melanogaster

Name

FlyBase ID

FBal0240411

Feature type

allele

Associated gene

Dmel\Hipk

Associated Insertion(s)

P{?'GT1}Hipk³

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Lee et al., 2009)

Progenitor genotype

P{GT1}Hipk^BG00855

(Lee et al., 2009)

Associated Insertion(s)

P{?'GT1}Hipk³

Caused by aberration

Df(3L)hipk³

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a deletion that extends 4.25kb from the 5' end of the original insertion. The deletion spans 3.73kb of the hipk locus and 370bp of the neighbouring Cypl gene. At least 4.34 kb of the progenitor inserted element is retained.

(Lee et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:542,549..546,799 [+]

Comment:

Apporximate boundaries of a deletion resulting from the imprecise excision of P{GT1}Hipk^BG00855, which is reported to remove 4.25kb including 3.73kb of the Hipk locus and 370bp of the adjacent Cypl gene.

(Lee et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(3L)ED4177)

(Lee et al., 2009)

lethal - all die before end of pupal stage | recessive

(Lee et al., 2009)

some die during pupal stage | recessive

(Lee et al., 2009)

visible | pharate adult stage (with Hipk²)

(Lee et al., 2009)

visible | pharate adult stage (with Hipk⁴)

(Lee et al., 2009)

Phenotype Manifest In

eye | pharate adult stage (with Hipk²)

(Lee et al., 2009)

eye | pharate adult stage (with Hipk⁴)

(Lee et al., 2009)

eye | pharate adult stage | ventral (with Hipk⁴)

(Lee et al., 2009)

eye photoreceptor cell

(Lee et al., 2009)

Detailed Description

Statement

Reference

hipk³/hipk⁴ pharate adults show preferential loss in the ventral region of the eye, resulting in a small round eye.

hipk²/hipk³ pharate adult eyes occasionally contain non-retinal tissue.

25% of homozygous eye discs show a loss of photoreceptor cells.

(Lee et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hipk³ has visible phenotype, enhanceable by Delta^eA7/Dl[+]

(Lee et al., 2009)

Enhancer of

Statement

Reference

Hipk³/Hipk⁴ is an enhancer of visible phenotype of Scer\GAL4^ey.PH, fng^UAS.cKa

(Lee et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hipk³ has eye phenotype, enhanceable by Delta^eA7/Dl[+]

(Lee et al., 2009)

Enhancer of

Statement

Reference

Hipk³/Hipk⁴ is an enhancer of eye phenotype of Scer\GAL4^ey.PH, fng^UAS.cKa

(Lee et al., 2009)

Hipk³ is an enhancer of wing margin phenotype of Axn^A2.UAS, Scer\GAL4^sd-SG29.1

(Lee et al., 2009)

Hipk³ is an enhancer of trichome of the posterior wing margin phenotype of Axn^A2.UAS, Scer\GAL4^sd-SG29.1

(Lee et al., 2009)

Suppressor of

Statement

Reference

Hipk³/Hipk³ is a suppressor of eye photoreceptor cell phenotype of N^ICN.UAS, Scer\GAL4^ey.PH

(Lee et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The severity of the small eye phenotype seen in hipk³ homozygotes is enhanced by Dl^eA7/+.

hipk³/hipk³ suppresses the loss of photoreceptors in the eye disc caused by expression of N^ICN.Scer\UAS under the control of Scer\GAL4^ey.PH.

The small eye phenotype caused by expression of fng^Scer\UAS.cKa under the control of Scer\GAL4^ey.PH is enhanced by hipk³/hipk⁴.

(Lee et al., 2009)

Heterozygosity for hipk³ enhances the severity of wing-notching and loss of posterior margin bristles seen in animals overexpressing Axn^A2.Scer\UAS under the control of Scer\GAL4^sd-SG29.1.

(Lee et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hipk³

hipk³

(Lee et al., 2009, Lee et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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