FB2024_02 , released April 23, 2024
Allele: Dmel\AkhRJF03256
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General Information
Symbol
Dmel\AkhRJF03256
Species
D. melanogaster
Name
FlyBase ID
FBal0242432
Feature type
allele
Associated gene
Dmel\AkhR
Associated Insertion(s)
Carried in Construct
P{TRiP.JF03256}
Also Known As
JF03256, UAS-AkhR-RNAi, UAS-AKHR RNAi, AkhR-i
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
in vitro construct - RNAi
(Perkins et al., 2009)
in vitro construct - regulatory fusion
(Perkins et al., 2009)
Progenitor genotype
Carried in construct
P{TRiP.JF03256}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF03256
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of AkhRJF03256 under the control of Scer\GAL4elav.PU in adult females does not affect locomotor activity in fed conditions, compared to controls; unlike controls, locomotor activity is not significantly increased under starvation conditions; loss of starvation-induced hyperactivity is also seen when AkhRJF03256 is expressed under the control of Scer\GAL4nSyb.PY or Scer\GAL4Tdc2.PC, but not Scer\GAL4ppl.PP or Scer\GAL4Gr5a.8.5; Scer\GAL4nSyb.PY-induced expression does not affect the starvation-induced increase in food intake and does not affect feeding behavior under starvation conditions, compared to controls.

      (Yu et al., 2016)

      AkhR knock-down in Insulin Producing Cells (Scer\GAL4Ilp2.215-1-mediated expression of AkhRJF03256) does not result in increased adiposity.

      (Alfa et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AkhRJF03256
      GRHRJF03256
      Name Synonyms
      Secondary FlyBase IDs
        References (11)