FlyBase Allele Report: Dmel\gogo[H1675]

General Information

Symbol

Dmel\gogo^H1675

Species

D. melanogaster

Name

FlyBase ID

FBal0242621

Feature type

allele

Associated gene

Dmel\gogo

Associated Insertion(s)

Carried in Construct

Also Known As

H1675

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Tomasi et al., 2008)

Mutagen

ethyl methanesulfonate

(Berger et al., 2008)

Progenitor genotype

Cytology

Description

Amino acid numbering based on PA isoform.

(Berger et al., 2008)

Amino acid replacement: Q255term.

(Berger et al., 2008, Tomasi et al., 2008)

Amino acid replacement: Q255@.

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:20,278,247..20,278,247 [-]

Nucleotide change:

C20278247T

Reported nucleotide change:

C?T

Amino acid change:

Q255term | gogo-PA

Reported amino acid change:

Q255term

(Tomasi et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | late embryonic stage (with gogo^D1600)

(Stratmann et al., 2019)

abnormal neuroanatomy | somatic clone

(Mann et al., 2012)

abnormal neuroanatomy | somatic clone | third instar larval stage

(Berger et al., 2008)

Phenotype Manifest In

apterous-expressing neuron of the lateral cluster of the thorax | late embryonic stage (with gogo^D1600)

(Stratmann et al., 2019)

medulla | somatic clone

(Mann et al., 2012)

photoreceptor neuron | somatic clone

(Mann et al., 2012, Tomasi et al., 2008)

Detailed Description

Statement

Reference

In gogo^H1675/gogo^D1600 embryos the axons of ap-expressing neurons are mildly disorganized, with no impact on the overall organization of the Fas2-immunopositive scaffold.

(Stratmann et al., 2019)

Homozygous gogo^H1675 eyes (generated using the eyFLP system) display a severe phenotype, with incomplete medulla rotation and the formation of abnormal bundles through an ectopic chiasm.

(Mann et al., 2012)

Photoreceptor axons do not project correctly in the optic lobe of gogo^H1675 eye-brain complexes in third instar larvae, while the photoreceptor cells themselves are appropriately specified.

(Berger et al., 2008)

All photoreceptors are present and properly located in tangential sections of the eye in animals in which the retina is homozygous (induced using the eyFLP method), but these animals show defects in the projections of photoreceptor axons.

(Tomasi et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

gogo^H1675 is an enhancer of partially lethal - majority die phenotype of stan^E86/stan^E59

(Hakeda-Suzuki et al., 2011)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

gogo^H1675/+ substantially increases the incidence of R8 photoreceptor axon defects in mosaic animals containing homozygous stan^E86 R8 photoreceptor axons.

(Hakeda-Suzuki et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

gogo^H1675 is rescued by gogo^{C2.GMR.Tag:MYC}

(Mann et al., 2012)

gogo^H1675 is rescued by gogo^{C1C2.GMR.Tag:MYC}

(Mann et al., 2012)

gogo^H1675 is rescued by gogo^{C2C3.GMR.Tag:MYC}

(Mann et al., 2012)

gogo^H1675 is rescued by gogo^GMR.Tag:MYC

(Mann et al., 2012)

gogo^H1675 is rescued by gogo^FFD.GMR

(Mann et al., 2012)

gogo^H1675 is rescued by gogo^FYD.GMR

(Mann et al., 2012)

gogo^H1675 is rescued by gogo^YFD.GMR

(Mann et al., 2012)

Partially rescued by

gogo^H1675 is partially rescued by gogo^{C2shortFFD.GMR}

(Mann et al., 2012)

Not rescued by

gogo^H1675 is not rescued by gogo^{C1.GMR.Tag:MYC}

(Mann et al., 2012)

gogo^H1675 is not rescued by gogo^{C3.GMR.Tag:MYC}

(Mann et al., 2012)

gogo^H1675 is not rescued by gogo^{C1C3.GMR.Tag:MYC}

(Mann et al., 2012)

gogo^H1675 is not rescued by gogo^ΔYYD.GMR

(Mann et al., 2012)

gogo^H1675 is not rescued by gogo^DDD.GMR

(Mann et al., 2012)

gogo^H1675 is not rescued by gogo^DYD.GMR

(Mann et al., 2012)

Comments

Expression of gogo^{GMR.T:Hsap\MYC} completely rescues the axon projection defects seen in gogo^H1675 mutant eye clones.

Expression of gogo^{C2.GMR.T:Hsap\MYC} completely rescues the axon projection defects seen in gogo^H1675 mutant eye clones.

Expression of gogo^{C1.GMR.T:Hsap\MYC} fails to rescue the axon projection defects seen in gogo^H1675 mutant eye clones.

Expression of gogo^{C3.GMR.T:Hsap\MYC} fails to rescue the axon projection defects seen in gogo^H1675 mutant eye clones.

Expression of gogo^{C1C2.GMR.T:Hsap\MYC} completely rescues the axon projection defects seen in gogo^H1675 mutant eye clones.

Expression of gogo^{C2C3.GMR.T:Hsap\MYC} completely rescues the axon projection defects seen in gogo^H1675 mutant eye clones.

Expression of gogo^{C1C3.GMR.T:Hsap\MYC} fails to rescue the axon projection defects seen in gogo^H1675 mutant eye clones.

Expression of gogo^ΔYYD.GMR fails to rescue the axon projection defects seen in gogo^H1675 mutant eye clones.

Expression of gogo^FFD.GMR completely rescues the axon projection defects seen in gogo^H1675 mutant eye clones.

Expression of gogo^DDD.GMR fails to rescue the axon projection defects seen in gogo^H1675 mutant eye clones.

Expression of gogo^DYD.GMR fails to rescue the axon projection defects seen in gogo^H1675 mutant eye clones.

Expression of gogo^YDD.GMR fails to rescue the axon projection defects seen in gogo^H1675 mutant eye clones.

Expression of gogo^FYD.GMR completely rescues the axon projection defects seen in gogo^H1675 mutant eye clones.

Expression of gogo^YFD.GMR completely rescues the axon projection defects seen in gogo^H1675 mutant eye clones.

Expression of gogo^{C2shortFFD.GMR} rescues most of the phenotypes seen in gogo^H1675 mutant eye clones. The medulla rotation is completely rescued, whereas the R8 targeting is only partially rescued (approximately 70% of R8 neurons target correctly).

(Mann et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

H1675

(Hakeda-Suzuki et al., 2011, Berger et al., 2008)

gogo^H1675

(Stratmann et al., 2019, Mann et al., 2012, Hakeda-Suzuki et al., 2011, Tomasi et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (6)

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