FB2024_03 , released June 25, 2024
Allele: Dmel\Sox21aJF02191
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General Information
Symbol
Dmel\Sox21aJF02191
Species
D. melanogaster
Name
FlyBase ID
FBal0244870
Feature type
allele
Associated gene
Dmel\Sox21a
Associated Insertion(s)
Carried in Construct
P{TRiP.JF02191}
Also Known As
UAS-Sox21aRNAi(TRiP)
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
in vitro construct
(Perkins et al., 2009)
Progenitor genotype
Carried in construct
P{TRiP.JF02191}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF02191
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  intestinal cancer
      CEA
      (Chen et al., 2016)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Sox21aJF02191 under the control of Scer\GAL4Su(H).GBE (using GAL80ts for temporal control) induces rapid accumulation of enteroblast-like cells in the intestinal epithelium.

      (Chen et al., 2016)

      Somatic MARCM clones of cells expressing Sox21aJF02191 under the control of Scer\GAL4tub.PU in the adult posterior midgut are significantly smaller compared to the control clones, although the overall number of clones recovered is comparable. Expression driven by the Scer\GAL4esg-NP5130 driver also reduces proliferation of intestinal stem cells in the adult gut.

      (Meng and Biteau, 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increased cell proliferation observed upon expression of either hepScer\UAS.cBa or Ras85DV12.Scer\UAS under the control of Scer\GAL4esg-NP5130 in the adult gut is strongly suppressed by co-expression Sox21aJF02191.

      (Meng and Biteau, 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Sox21aJF02191
      Name Synonyms
      Secondary FlyBase IDs
        References (5)