FB2024_03 , released June 25, 2024
Allele: Dmel\Rabex-5DPYT.UAS.Tag:MYC
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General Information
Symbol
Dmel\Rabex-5DPYT.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0246626
Feature type
allele
Associated gene
Dmel\Rabex-5
Associated Insertion(s)
Carried in Construct
P{UAS-Rabex-5.DPYT.MYC}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Yan et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Rabex-5.DPYT.MYC}
Cytology
Description

UAS regulatory sequences drive expression of a mutant form Rabex-5 tagged with Tag:MYC. The are alterations are designed to inactivate the RAB5 GEF activity of Rabex-5.

(Yan et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Rabex-5
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Rabex-5DPYT.Scer\UAS.T:Hsap\MYC in the posterior wing driven by Scer\GAL4en-e16E results in the loss of crossveins and the loss of the distal part of longitudinal vein L5.

      (Yan et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Rabex-5DPYT.Scer\UAS.T:Hsap\MYC driven by Scer\GAL4GMR.PU reduces the roughness, eye size, and black tissue phenotypes of Ras85DV12.S35.Scer\UAS-expressing eyes. The change in roughness is subtle.

      (Yan et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rabex-5DPYT.Scer\UAS.T:Hsap\MYC
      Rabex-5DPYT.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (3)