FB2024_03 , released June 25, 2024
Allele: Dmel\veli66
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General Information
Symbol
Dmel\veli66
Species
D. melanogaster
Name
FlyBase ID
FBal0246669
Feature type
allele
Associated gene
Dmel\veli
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Bachmann et al., 2008)
Progenitor genotype
P{EP}veliGE20172
(Bachmann et al., 2008)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 448bp deletion which includes part of the first exon (including the translation start site) and all of the second exon of veli.

(Bachmann et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:25,065,102..25,065,549 [-]
Comment:

448 bp deletion resulting from the imprecise excsion of P{EP}veliGE20172, which extends from the insertion site into veli.

(Bachmann et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants show a 30% reduction in the number of boutons/muscle surface area at the neuromuscular junction (NMJ) compared to controls. The mean projection area of type Ib boutons at the NMJ is increased by 63% in mutants compared to controls.

      (Bachmann et al., 2010)

      veli66 mutant heads do not show any size differences compared to wild-type heads.

      (Richardson and Pichaud, 2010)

      Photoreceptor cells of mutant flies kept in the dark for 13 days have a wild-type morphology. The mutants show light-dependent retinal degeneration after 7 days of constant light exposure which can be prevented by raising the flies on a medium lacking vitamin A.

      (Bachmann et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      veli66 is a suppressor of neoplasia phenotype of Scer\GAL4rn-GAL4-5, crbintra.UAS

      (Andersen et al., 2015)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      veli66 is partially rescued by Scer\GAL4RapGAP1-OK6/veliUAS.Tag:FLAG/Scer\GAL4C57

      (Bachmann et al., 2010)
      Comments

      Expression of veliScer\UAS.T:Zzzz\FLAG under the control of both Scer\GAL4OK6 and Scer\GAL4C57 largely rescues the increased projection area of type Ib boutons at the neuromuscular junction which is seen in veli66 mutants.

      (Bachmann et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      DLin-7*66
      (Bachmann et al., 2010)
      DLin7*66
      (Bachmann et al., 2008)
      Dlin-766
      (Soukup et al., 2013)
      dLin-7#66
      (Bachmann et al., 2010)
      lin-766
      (Richardson and Pichaud, 2010)
      lin766
      (Richardson and Pichaud, 2010)
      veli66
      (Andersen et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)