Amino acid replacement: Q561term.
C8317756T
Q561term | mtsh-PC; Q561term | mtsh-PD
Q561term
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
Mitochondria aggregate aberrantly in spermatocytes and spermatids in mtshZ2-3484 homozygotes or mtshZ2-2620/mtshZ2-3484 males. Primary spermatocytes appear normal, but mitochondria aggregate abnormally early in late primary spermatocytes before meiotic divisions. As a result, mitochondria aggregate in a single shell surrounding each premeiotic nucleus instead of in a separate body beside each postmeiotic nucleus as in wild type. Mutant spermatocytes undergo karyokinesis with the resulting 4 nuclei staying adjacent to each other within a single mitochondrial shell. Meiotic cytokinesis is never observed, though spermatid bundle elongation and other subsequent events of spermiogenesis do occur. Spermatid tails appear irregularly packed. The resulting sperm cells are not individualized.
From the Zuker collection.