FB2024_03 , released June 25, 2024
Allele: Scer\GAL4Gr28a.PT
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General Information
Symbol
Scer\GAL4Gr28a.PT
Species
S. cerevisiae
Name
FlyBase ID
FBal0247205
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{Gr28a-GAL4.T}
Also Known As
Gr28a-GAL4
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Thorne and Amrein, 2008)
Progenitor genotype
Carried in construct
P{Gr28a-GAL4.T}
Cytology
Description

A 1200bp fragment containing the Gr28a promoter region regulates expression of a GAL4 driver.

(Thorne and Amrein, 2008)
Allele components
Component
Use(s)
Regulatory region(s)
Gr28a
Gr28a_1200bp
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      larval stage
      terminal organ | restricted
      (Thorne and Amrein, 2008)
      third instar larval stage
      gustatory receptor neuron of terminal organ
      (Kwon et al., 2011)
      gustatory receptor neuron of the dorsal organ
      (Kwon et al., 2011)
      larval hypopharyngeal organ gustatory receptor neuron
      (Kwon et al., 2011)
      gustatory receptor neuron of the hypophysis
      (Kwon et al., 2011)
      larval gnathal ganglion
      (Kwon et al., 2011)
      larval gustatory receptor neuron of the hypophysis VP3
      (Choi et al., 2016)
      larval gustatory receptor neuron of the hypophysis VP4
      (Choi et al., 2016)
      larval gustatory receptor neuron of the hypophysis VP5
      (Choi et al., 2016)
      larval gustatory receptor neuron of the hypopharyngeal organ PP3
      (Choi et al., 2016)
      larval gustatory receptor neuron of the hypopharyngeal organ PP4
      (Choi et al., 2016)
      larval gustatory receptor neuron of the hypopharyngeal organ PP5
      (Choi et al., 2016)
      larval gustatory receptor neuron of the hypopharyngeal organ PP6
      (Choi et al., 2016)
      abdominal 1 ventral multidendritic neuron v'td1
      (Qian et al., 2018)
      abdominal 1 ventral multidendritic neuron v'td2
      (Qian et al., 2018)
      abdominal 2 ventral multidendritic neuron v'td2
      (Qian et al., 2018)
      abdominal 3 ventral multidendritic neuron v'td2
      (Qian et al., 2018)
      gustatory receptor neuron of terminal organ | subset
      (Mishra et al., 2018)
      larval hypopharyngeal organ gustatory receptor neuron | subset
      (Mishra et al., 2018)
      larval ventral nerve cord | restricted
      (Mishra et al., 2018)
      multidendritic neuron | subset
      (Mishra et al., 2018)
      embryonic/larval midgut | restricted
      (Mishra et al., 2018)
      adult stage
      high salt/bitter-sensing neuron | subset of prothoracic tarsal segment 5
      (Ling et al., 2014)
      gustatory receptor neuron | subset
      (Thorne and Amrein, 2008)
      gustatory receptor neuron | subset of ventral cibarial sense organ
      (Thorne and Amrein, 2008)
      gustatory receptor neuron of short labellar taste bristle | subset
      (Thorne and Amrein, 2008)
      gustatory receptor neuron of intermediate labellar taste bristle | subset
      (Thorne and Amrein, 2008)
      gustatory receptor neuron | faint | subset of prothoracic tarsal segment 5
      (Thorne and Amrein, 2008)
      maxillary palp | restricted
      (Thorne and Amrein, 2008)
      campaniform sensillum | subset of wing vein L3
      (Thorne and Amrein, 2008)
      mechanosensory neuron | subset of leg
      (Thorne and Amrein, 2008)
      dendritic arborizing neuron | subset of abdomen | dorsal
      (Thorne and Amrein, 2008)
      gnathal ganglion | restricted
      (Thorne and Amrein, 2008)
      antennal lobe glomerulus VM3
      (Thorne and Amrein, 2008)
      gustatory receptor neuron | subset of short labellar taste bristle | subset
      (Weiss et al., 2011)
      gustatory receptor neuron | subset of intermediate labellar taste bristle | subset
      (Weiss et al., 2011)
      high salt/bitter-sensing neuron of adult labellum sensillum
      (Weiss et al., 2011)
      L-type sensillum L1
      (Weiss et al., 2011, Weiss et al., 2011)
      L-type sensillum L2
      (Weiss et al., 2011)
      L-type sensillum L4
      (Weiss et al., 2011, Weiss et al., 2011)
      L-type sensillum L6
      (Weiss et al., 2011, Weiss et al., 2011)
      L-type sensillum L8
      (Weiss et al., 2011)
      L-type sensillum L9
      (Weiss et al., 2011)
      L-type sensillum L5
      (Weiss et al., 2011, Weiss et al., 2011)
      L-type sensillum L7
      (Weiss et al., 2011, Weiss et al., 2011)
      intermediate labellar taste bristle I-b
      (Weiss et al., 2011)
      short labellar taste bristle S-b
      (Weiss et al., 2011)
      L-type sensillum L2 | intense
      (Weiss et al., 2011)
      L-type sensillum L8 | intense
      (Weiss et al., 2011)
      L-type sensillum L9 | intense
      (Weiss et al., 2011)
      short labellar taste bristle S-a | intense
      (Weiss et al., 2011)
      short labellar taste bristle S-b | intense
      (Weiss et al., 2011)
      intermediate labellar taste bristle I-b | intense
      (Weiss et al., 2011)
      adult abdominal multidendritic neuron | subset
      (Park and Kwon, 2011)
      short labellar taste bristle S-a
      (Weiss et al., 2011)
      Additional Information
      Statement
      Reference

      ScerGAL4Gr28a.PT drives expression in the following series of neurons. Larval gustatory receptor neuron of the hypophysis VP3, where it may coexpress with ScerGAL4Gr68a.PB, VP4 and VP5. Larval gustatory receptor neuron of the hypopharyngeal organ PP3 where it is coexpressed with ScerGAL4Gr33a.4.7, ScerGAL4Gr66a.1.8, ScerGAL4Gr32a.3.7.PW, ScerGAL4Gr22b.5.8, ScerGAL4Gr39a.a.3.4, ScerGAL4Gr39b.4.4, ScerGAL4Gr39a.d.1.7, ScerGAL4Gr93c.3.8 and ScerGAL4Gr93d.2.4 Larval gustatory receptor neuron of the hypopharyngeal organ PP4 where it is coexpressed with ScerGAL4Gr33a.4.7, ScerGAL4Gr66a.1.8, ScerGAL4Gr22b.5.8, ScerGAL4Gr39a.a.3.4, ScerGAL4Gr39b.4.4, ScerGAL4Gr39a.d.1.7, ScerGAL4Gr93c.3.8 and ScerGAL4Gr93d.2.4. Larval gustatory receptor neuron of the hypopharyngeal organ PP5 and PP6 where it is coexpressed with ScerGAL4Gr93d.2.4.

      (Choi et al., 2016)

      ScerGAL4Gr28a.PT drives expression in adult abdominal multidendritic neurons with with dorsal processes extending along the left-right axis, as well as in multidendritic neurons with lateral processes extending anteroposteriorly; these major processes have several protruding dendrites. Additionally, expression is driven in multidendritic neurons with ladder-like processes along the dorsal abdominal wall.

      (Park and Kwon, 2011)

      ScerGAL4Gr28a.PT is expressed in gustatory neurons of all of the bitter-sensitive small labellar taste bristles, and in gustatory neurons of the three posterior-most intermediate labellar taste bristles.

      (Weiss et al., 2011)

      ScerGAL4Gr28a.PT is expressed in all of the short and in a few of the intermediate bitter-sensitive sensilla of the labellum.

      (Weiss et al., 2011, Weiss et al., 2011)

      ScerGAL4Gr28a.PT drives expression in two gustatory receptor neurons of the larval terminal organ, two neurons of the dorsal organ, two neurons of the posterior pharyngeal sense organ (PPS or hypopharyngeal sense organ) and in two neurons of the ventral pharyngeal sense organ (VPS or hypophysis). The two neurons of the dorsal organ also express ScerGAL4Gr2a.2.2.

      (Kwon et al., 2011)

      Expression of ScerGAL4Gr28a.PT is seen in approximately 32 neurons per labial palp. ScerGAL4Gr28a.PT is found to be expressed in a single neuron associated with the ventral cibarial sense organ. Expression of ScerGAL4Gr28a.PT is seen in two neurons associated with the fifth tarsal segment of the adult foreleg. Expression of ScerGAL4Gr28a.PT is seen in a single, large cell at the base of the maxillary palpus that is not an olfactory sensory neuron. Expression is seen in leg neurons thought to be stretch receptors or proprioreceptors. In the larva, expression is seen in a single neuron per ventral pit of the terminal organ.

      (Thorne and Amrein, 2008)
       
      Marker for
      Reflects expression of
      Gr28a
      (Ling et al., 2014, Kwon et al., 2011, Park and Kwon, 2011, Weiss et al., 2011, Weiss et al., 2011, Thorne and Amrein, 2008)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ablation of Scer\GAL4Gr28a.PT-expressing neurons does not affect sensitivity to the gustatory sex pheromone (S,Z,Z)-CH503: as in wild type, courtship defects are seen in these flies in response to (S,Z,Z)-CH503.

      (Shankar et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Scer\GAL4Gr28a.PT
      Name Synonyms
      Secondary FlyBase IDs
        References (20)