FlyBase Allele Report: Dmel\SMC2[HMS00360]

General Information

Symbol

Dmel\SMC2^HMS00360

Species

D. melanogaster

Name

FlyBase ID

FBal0248125

Feature type

allele

Associated gene

Dmel\SMC2

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00360}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00360}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00360

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

male germline stem cell | adult stage, with Scer\GAL4^C587

(Liu et al., 2016)

male germline stem cell | adult stage, with Scer\GAL4^{VP16.nanos.UTR}

(Liu et al., 2016)

testis | adult stage, with Scer\GAL4^C587

(Liu et al., 2016)

testis | adult stage, with Scer\GAL4^{VP16.nanos.UTR}

(Liu et al., 2016)

Detailed Description

Statement

Reference

Expression of SMC2^HMS00360 under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} results in dramatic loss of germline stem cells (GMC) in the adult testes, whereas expression under Scer\GAL4^C587 leads to GMC differentiation defects and Scer\GAL4^{bam.T:Hsim\VP16}-driven expression has no obvious effect on the cells.

(Liu et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions