FB2024_03 , released June 25, 2024
Allele: Scer\GAL4GMR16A06
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General Information
Symbol
Scer\GAL4GMR16A06
Species
S. cerevisiae
Name
FlyBase ID
FBal0250081
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{GMR16A06-GAL4}
Also Known As
R16A06-GAL4, R16A06
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Pfeiffer et al., 2011.2.9)
Progenitor genotype
Carried in construct
P{GMR16A06-GAL4}
Cytology
Description

A 1212 base pair fragment from the flanking non-coding or intronic region of Plc21C is fused upstream of a Drosophila core synthetic promoter (DSCP) that is followed by sequence encoding a GAL4 driver.

(Pfeiffer et al., 2011.2.9)
Allele components
Component
Use(s)
Regulatory region(s)
GMR16A06
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      gamma Kenyon cell
      (Wu et al., 2018, Shyu et al., 2017, Cohn et al., 2015)
      adult mushroom body | intense | restricted
      (Jenett and Svirskas, 2012.9.24)
      inferior clamp | intense | restricted
      (Jenett and Svirskas, 2012.9.24)
      adult brain | restricted
      (Shyu et al., 2017)
      Additional Information
      Statement
      Reference
       
      Marker for
      gamma Kenyon cell
      (Cohn et al., 2015)
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Inhibition (using shi1.UAS at 32[o]C) of Scer\GAL4GMR16A06 cells in adults does not affect startle-induced climbing behavior, compared to controls.

      Thermogenetic activation (using TrpA1UAS.(B).cKa at 32[o]C) of Scer\GAL4GMR16A06 cells in adults significantly reduces startle-induced climbing behavior, compared to controls, without causing paralysis; thermogenetic activation of the combined set of Scer\GAL4GMR16A06 and Scer\GAL4Mef2.247 cells in adults significantly reduces startle-induced climbing behavior, compared to controls, but this phenotype is significantly less severe than activation of Scer\GAL4GMR16A06 cells alone.

      Optogenetic activation (using Crei\ChR2XXL.UAS with blue light) of Scer\GAL4GMR16A06 cells in adults significantly reduces startle-induced climbing behavior, compared to controls.

      (Sun et al., 2018)

      Inhibition (using shits1.IVS.p10.20xUAS at 32[o]C) of Scer\GAL4GMR16A06 cells in adults during retrieval alone, but not acquisition and consolidation, significantly reduces 24-hour associative olfactory water-reward memory, compared to controls; inhibition has no effect on odor acuity or water preference, compared to controls.

      (Shyu et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Scer\GAL4GMR16A06
      Name Synonyms
      Secondary FlyBase IDs
        References (18)