FB2024_03 , released June 25, 2024
Allele: Dmel\Klp67AUbi-p63E.GFP
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General Information
Symbol
Dmel\Klp67AUbi-p63E.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0258597
Feature type
allele
Associated gene
Dmel\Klp67A
Associated Insertion(s)
Carried in Construct
P{Ubi-Klp67A.GFP}
Key Links
Transgenic product class
wild_type
(Wang et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Wang et al., 2010)
Mutagen
in vitro construct
(Wang et al., 2010)
Progenitor genotype
Carried in construct
P{Ubi-Klp67A.GFP}
Cytology
Description

Ubi-p63E regulatory sequences drive expression of Klp67A tagged with GFP.

(Wang et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
Ubi-p63E
Encoded product / tool
Klp67A
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Klp67AUbi-p63E.T:Avic\GFP restores fertility and viability to Klp67A322b24/Df(3L)29A6 mutants. The major mitotic defect caused by depletion of Klp67A in the mutant embryos is rescued by Klp67AUbi-p63E.T:Avic\GFP. Klp67AUbi-p63E.T:Avic\GFP restores wild-type spindle morphology and geometry and the dynamics of mitotic spindle poles in the rescued flies is virtually identical to that seen in wild-type embryos.

      (Wang et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Klp67AUbi-p63E.GFP rescues Df(3L)29A6/Klp67A322b24

      (Wang et al., 2010)
      Comments

      Klp67AUbi-p63E.T:Avic\GFP restores fertility and viability to Klp67A322b24/Df(3L)29A6 mutants. The major mitotic defect caused by depletion of Klp67A in the mutant embryos is rescued by Klp67AUbi-p63E.T:Avic\GFP. Klp67AUbi-p63E.T:Avic\GFP restores wild-type spindle morphology and geometry and the dynamics of mitotic spindle poles in the rescued flies is virtually identical to that seen in wild-type embryos.

      (Wang et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Klp67AUbi-p63E.GFP
      Klp67AUbi-p63E.T:Avic\GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (3)