FB2024_03 , released June 25, 2024
Allele: Hsap\UBBtetO.cHa
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General Information
Symbol
Hsap\UBBtetO.cHa
Species
H. sapiens
Name
Tn10 tetracycline operator construct a of Hoe
FlyBase ID
FBal0258685
Feature type
allele
Associated gene
Hsap\UBB
Associated Insertion(s)
Carried in Construct
P{tetO-UBB.H}
Key Links
Transgenic product class
wild_type
(Hoe et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Hoe et al., 2011)
Mutagen
in vitro construct
(Hoe et al., 2011)
Progenitor genotype
Carried in construct
P{tetO-UBB.H}
Cytology
Description

A wild-type Hsap\UBB-monomer is expressed under the control of tetO operator sequences.

(Hoe et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
tetO
Encoded product / tool
Hsap\UBB
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of Hsap\UBBTn10\tetO.cHa under the control of Tn10\tetRAct5C.T:Hsim\VP16 results in lethality. The lethality caused by Hsap\UBBTn10\tetO.cHa-overexpression is associated with a dramatic disruption of normal pupal structures and large melanotic inclusions indicative of extensive cell death.

      Overexpression of Hsap\UBBTn10\tetO.cHa under the control of Scer\GAL4da.G32 and Tn10\tetRM2.alt.Scer\UAS.T:Hsim\VP16 does not decrease the survival-rate in adults. Instead, overexpression of Hsap\UBB+1.Tn10\tetO results in a slight increase in male life span.

      (Hoe et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\UBBTn10\tetO.cHa
      Hsap\UBBtetO.cHa
      Name Synonyms
      Tn10 tetracycline operator construct a of Hoe
      Secondary FlyBase IDs
        References (1)