FB2024_03 , released June 25, 2024
Allele: Hsap\UBB+1.tetO
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General Information
Symbol
Hsap\UBB+1.tetO
Species
H. sapiens
Name
FlyBase ID
FBal0258686
Feature type
allele
Associated gene
Hsap\UBB
Associated Insertion(s)
Carried in Construct
P{tetO-UBB.+1}
Key Links
Transgenic product class
frameshift_truncation
(Hoe et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
frameshift_truncation
(Hoe et al., 2011)
Mutagen
in vitro construct
(Hoe et al., 2011)
Progenitor genotype
Carried in construct
P{tetO-UBB.+1}
Cytology
Description

A frame-shifted version of Hsap\UBB resulting from a dinucleotide deletion adjacent to a GAGAG motif is expressed under the control of tetO operator sequences.

(Hoe et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
tetO
Encoded product / tool
Hsap\UBB
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of Hsap\UBB+1.Tn10\tetO under the control of Tn10\tetRAct5C.T:Hsim\VP16 does not cause decreased survival or pupal abnormalities.

      When Hsap\UBB+1.Tn10\tetO is overexpressed in adult flies under the control of Scer\GAL4da.G32 and Tn10\tetRM2.alt.Scer\UAS.T:Hsim\VP16, it is found to have a small negative effect on survival, particularly in males.

      (Hoe et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\UBB+1.Tn10\tetO
      Hsap\UBB+1.tetO
      Name Synonyms
      Secondary FlyBase IDs
        References (1)