Flies expressing arudsRNA.Scer\UAS pan-organismally under the control of Scer\GAL4tub.PU fail to survive.
Flies with reduced neuronal aru through expression of arudsRNA.Scer\UAS under the control of Scer\GAL4elav-C155 show a significant increase in sensitivity to ethanol sedation. Neuronal knockdown of aru expression throughout development (until eclosion of the fly) increases sensitivity to ethanol sedation. Expression after eclosion has no effect.
Expression of arudsRNA.Scer\UAS under the control of Scer\GAL4P2.4.Pdf increases ethanol sensitivity.