FB2024_03 , released June 25, 2024
Allele: Dmel\CanA-14FUAS.Tag:MYC
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General Information
Symbol
Dmel\CanA-14FUAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0266873
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UAS regulatory sequences drive expression of a 1814bp CanA-14F coding fragment, fused with a Tag:MYC, immediately upstream of a stop codon.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies expressing CanA-14FScer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav-C155, where expression is suppressed at the restrictive temperature of 19[o]C, are viable and do not have visible developmental defects. A temperature shift to 30[o]C for 2 days (after 3 days development at 19[o]C) markedly decreases nighttime sleep in control flies and in those from the progeny of the Scer\GAL4elav-C155; Scer\GAL80ts.αTub84B x CanA-14FScer\UAS.T:Hsap\MYC cross in both LD and DD, with no significant difference in their sleep levels before or after the temperature shift. This effect is most pronounced during night time, when control flies and CanA-14FScer\UAS.T:Hsap\MYC-expressing flies are highly active at 30[o]C.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CanA-14FScer\UAS.T:Hsap\MYC
CanA-14FUAS.Tag:MYC
Name Synonyms
Secondary FlyBase IDs
    References (2)