Expression of Hsap\HTTQ96.Scer\UAS.T:Avic\GFP with a weak elav-GAL4 driver (Scer\GAL4elav.PLu) results in viable adults that appear behaviourally normal at the time of eclosion. However, several days after eclosion these adults begin to exhibit motor coordination defects and abnormal grooming behaviours, worsening with age and resulting in premature death. The time taken for 50% of flies to die is 50% shorter than in controls.
Third instar larvae expressing Hsap\HTTQ96.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4elav-C155 form distinct cytoplasmic aggregates in salivary gland cells and CNS and PNS neurons. Aggregates also form in axons and localised at nerve terminals.