FlyBase Allele Report: Dmel\Sce[KO]

General Information

Symbol

Dmel\Sce^KO

Species

D. melanogaster

Name

FlyBase ID

FBal0268443

Feature type

allele

Associated gene

Dmel\Sce

Associated Insertion(s)

TI{TI}Sce^KO

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

ends-out gene targeting

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Gutiérrez et al., 2012)

Mutagen

ends-out gene targeting

(Gutiérrez et al., 2012)

Progenitor genotype

Associated Insertion(s)

TI{TI}Sce^KO

Cytology

Description

The entire Sce coding region being replaced by a w^+mW.hs marker.

(Gutiérrez et al., 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Luo-Schoch-Yamamoto syndrome

CEC

(Luo et al., 2021)

CEC with Sce^33M2

(Luo et al., 2021)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of Luo-Schoch-Yamamoto syndrome

is ameliorated by Sce^{S77N.Scer\FRT.gen}

(Luo et al., 2021)

is ameliorated by Sce^Scer\FRT.gen

(Luo et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

homeotic | adult stage | somatic clone

(Pengelly et al., 2015)

homeotic | embryonic stage

(Pengelly et al., 2015)

lethal - all die during embryonic stage

(Pengelly et al., 2015)

Phenotype Manifest In

microchaeta | somatic clone

(Pengelly et al., 2015)

Detailed Description

Statement

Reference

Sce^KO mutant (both zygotically and maternally) embryos display homeotic transformation phenotype with thoracic and abdominal segments T1-A7 transformed into copies resembling A8.

Sce^KO zygotic mutants all die at the end of embryogenesis.

Homeotic transformation of abdominal bristles (bristles in A2 segment resembling those characteristic for A10) is observed in adults bearing somatic clones of Sce^KO homozygous cells.

(Pengelly et al., 2015)

Eye discs composed mainly of homozygous cells are morphologically normal.

The cuticle is indistinguishable from wild type in homozygous stage 16 embryos.

(Gutiérrez et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Sce^KO is an enhancer of embryonic/first instar larval cuticle phenotype of Asx^22P4

(Gutiérrez et al., 2012)

Sce^KO is an enhancer of embryonic abdominal segment 8 | ectopic phenotype of Asx^22P4

(Gutiérrez et al., 2012)

Suppressor of

Statement

Reference

Sce^KO is a suppressor | partially of spermatid | germline clone | absent phenotype of Scer\GAL4^vas.PU, TER94^GD9777

(Butsch et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Sce^KO enhances the segmentation defects seen in Asx^22P4 embryos: segments T2-A7 in the cuticle are extensively, but not completely, transformed into copies of A8 in stage 16 double homozygous embryos.

(Gutiérrez et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Sce¹

(Gutiérrez et al., 2012)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

80157

w^*; P{neoFRT}82B cu¹ sr¹ Sce^KO/TM3, P{GAL4-twi.G}2.3, P{UAS-2xEGFP}AH2.3, Sb¹ Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Sce⁰

(Bonnet et al., 2022)

Sce^KO4

(Dardalhon-Cuménal et al., 2018)

Sce^KO

(Butsch et al., 2023, Bonnet et al., 2022, Luo et al., 2021, DeLuca et al., 2020, Lv et al., 2018, Shih et al., 2016, Pengelly et al., 2015, Gutiérrez et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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