FlyBase Allele Report: Dmel\parvin[694]

General Information

Symbol

Dmel\parvin⁶⁹⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0277792

Feature type

allele

Associated gene

Dmel\parvin

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Vakaloglou et al., 2012)

Mutagen

P-element activity

(Vakaloglou et al., 2012)

Progenitor genotype

P{EPgy2}parvin^EY03677

(Vakaloglou et al., 2012)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a deletion of sequences encoding parvin amino acid residues 1-278.

(Vakaloglou et al., 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:19,746,121..19,747,600 [+]

Comment:

Deletion resulting from the imprecise excision of P{EPgy2}parvin^EY03677, extends from the insertion site and removes the first 278 amino acids of parvin. Endpoints inferred.

(Vakaloglou et al., 2012)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage

(Vakaloglou et al., 2012)

some die during embryonic stage

(Vakaloglou et al., 2012)

Phenotype Manifest In

Detailed Description

Statement

Reference

Mutants die at the late embryonic stage. F-actin is pulled away from the muscle attachment sites in the mutant stage 17 embryos.

(Vakaloglou et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

parvin⁶⁹⁴ ; Ilk⁵⁴ stck^T2 triple mutant embryos have actin clumps that are detached from the muscle attachment sites, as occurs in single mutant embryos.

(Vakaloglou et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

parvin⁶⁹⁴ is rescued by parvin^7.2.mGFP6

(Vakaloglou et al., 2012)

Partially rescued by

parvin⁶⁹⁴ is partially rescued by Scer\GAL4^how-24B/parvin^UASp.cVa

(Vakaloglou et al., 2012)

Not rescued by

parvin⁶⁹⁴ is not rescued by parvin^3.5.mGFP6

(Vakaloglou et al., 2012)

Comments

Expression of parvin^Scer\UAS.cVa under the control of Scer\GAL4^how-24B almost completely rescues the lethality of parvin⁶⁹⁴ (90% of the expected adult flies are recovered). The rescued adults have blisters in both wings.

(Vakaloglou et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

600253

w^* parvin⁶⁹⁴; P{parvin-GFP.7.2}2/CyO

600149

P{parvin-mTFP1}1, w^* parvin⁶⁹⁴; P{Ilk.Venus}3, Ilk⁵⁴/TM6B, P{Dfd-EYFP}3, Sb¹ Tb¹ ca¹

600150

P{parvin-mTFP1}1, w^* parvin⁶⁹⁴; P{Venus.Ilk}3, Ilk⁵⁴/TM6B, P{Dfd-EYFP}3, Sb¹ Tb¹ ca¹