Under constant darkness conditions, flies expressing dom^HMS01855 under the control of either Scer\GAL4^tim.PE or Scer\GAL4^P2.4.Pdf (in combination with Dicer-2, for more efficient RNAi), frequently lose circadian rhythmicity and circadian periods become longer, as compared to controls; upon expression under the combined control of Scer\GAL4^tim.PE and Scer\GAL80^Pdf.PS, periods become longer despite of no changes in rhythmicity, as compared to controls.

Under LD cycles, flies expressing dom^HMS01855 under the control of Scer\GAL4^tim.PE (in combination with Dicer-2, for more efficient RNAi), do not show the expected morning peak of anticipatory activity.

Expression of dom^HMS01855 under the control of Scer\GAL4^bbg-C96 results in a majority of flies exhibiting wing nicks, and some showing defective wing margins, in contrast to controls.

Expression of dom^HMS01855 under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{otu.T:Hsim\VP16} causes significantly decreased female fertility, as compared to controls.

Expression of dom^HMS01855 under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} results in a significant reduction in egg-laying, as compared to controls.

Expression of dom^HMS01855 under the control of Scer\GAL4^tj.PU or Scer\GAL4^C587 leads to severe packaging defects during oogenesis, ranging from two cysts in a single egg chamber to complete ovariole fusions; many germaria show additional stalk-like structures without germline cysts, and egg laying is nearly completely abolished, as compared to controls.