FB2024_03 , released June 25, 2024
Allele: Dmel\maelS138A.UASp.Tag:FLAG
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General Information
Symbol
Dmel\maelS138A.UASp.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0281983
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Progenitor genotype
Carried in construct
Cytology
Description

UASp regulatory sequences drive expression of a mutated form of mael which contains the amino acid replacement S138A (preventing phosphorylation at this site). The protein is tagged with Tag:FLAG.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Expression of maelS138A.Scer\UAS.P\T.T:Zzzz\FLAG under the control of Scer\GAL4nos.PG does not suppress the defect in oocyte commitment (high frequency of 'two-oocyte phenotype' in region 3 of the germarium) that is seen in polo1/poloS025604 germaria.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of maelS138A.Scer\UAS.P\T.T:Zzzz\FLAG under the control of Scer\GAL4nos.PG rescues the differentiation defect seen in maelM391/Df(3L)79E-F ovaries, such that the number of germline stem cells and cystoblasts returns to normal and robust differentiation is seen.

Expression of maelS138A.Scer\UAS.P\T.T:Zzzz\FLAG under the control of Scer\GAL4nos.PG does not rescue the defect in oocyte commitment (high frequency of 'two-oocyte phenotype' in region 3 of the germarium) that is seen in maelM391/Df(3L)79E-F germaria.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
maelS138A.Scer\UAS.P\T.T:Zzzz\FLAG
maelS138A.UASp.Tag:FLAG
Name Synonyms
Secondary FlyBase IDs
    References (2)