Adults expressing drd^GD15915 under the control of either Scer\GAL4^DJ626 or Scer\GAL4^DJ717 (in combination with a Dicer-2 transgene to enhance RNAi efficiency) lack a peritrophic membrane in the midgut and have reduced defecation rates. Alongside, the presence of holes in the brain indicate signs of neurodegeneration.

Expressing drd^GD15915 under the control of Scer\GAL4^hs.PB hinders peritrophic membrane formation only when adult flies are heat-shocked for a prolonged period of time (12 days).

Expressing drd^GD3367 under the control of Scer\GAL4^DJ628 does not affect peritrophic membrane formation or adult survival.

Male flies expressing drd^GD15915 (in the presence of Dcr-2^Scer\UAS.cDa to increase RNAi efficiency) under the control of Scer\GAL4^hs.PB during the adult stage (moved to 30[o]C after eclosion) show no significant difference in lifespan compared to controls.

Temperature shift experiments using flies carrying drd^GD15915 and Scer\GAL4^hs.PB (in the presence of Dcr-2^Scer\UAS.cDa to increase RNAi efficiency) indicate that expression of drd^GD15915 during the final 48 hours of metamorphosis results in short lived adults.

Temperature shift experiments using flies carrying drd^GD15915 and Scer\GAL4^hs.PB (in the presence of Dcr-2^Scer\UAS.cDa to increase RNAi efficiency) indicate that expression of drd^GD15915 throughout all pre-adult development is required for newly eclosed adults to have a significantly reduced body mass compared to controls.