FB2024_03 , released June 25, 2024
Allele: Dmel\ScrHD.UAS
Open Close
General Information
Symbol
Dmel\ScrHD.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0282596
Feature type
allele
Associated gene
Dmel\Scr
Associated Insertion(s)
Carried in Construct
P{UAS-Scr.HD.WT}
Key Links
Transgenic product class
inframe_deletion
(Papadopoulos et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Papadopoulos et al., 2010)
Mutagen
in vitro construct
(Papadopoulos et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Scr.HD.WT}
Cytology
Description

UAS regulatory sequences drive expression of the wild-type Scr C terminus containing the YPWM motif and the homeodomain (HD).

(Papadopoulos et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Scr
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of ScrHD.Scer\UAS under the control of Scer\GAL4hs.PB induces ectopic salivary glands in the embryonic head.

      Ectopic expression of ScrHD.Scer\UAS under the control of Scer\GAL4Dll-md23 triggers homeotic transformation of the third antennal segment (A3) and the arista to a fully grown tarsus. The ectopic tarsi generated by Scer\GAL4Dll-md23>ScrHD.Scer\UAS display a patch of red pigmentation, an indication that a group of cells might have been transformed to ectopic eye-cells. The ectopic tarsi display one or two sex comb teeth indicating a prothoracic (T1) character.

      Scanning Electron Microscopy and the presence of photoreceptor cell markers of adult antennae expressing Scer\GAL4Dll-md23>ScrScer\UAS.cAa confirm that the pigmented cells observed are indeed ectopic compound eyes, comprising of several ommatidia.

      Ectopic expression of ScrScer\UAS.cAa using Scer\GAL4dpp.blk1 induces strong eye phenotypes, ranging from reduction to the complete absence of eyes.

      (Papadopoulos et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ScrHD.Scer\UAS
      ScrHD.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)