FB2024_03 , released June 25, 2024
Allele: Zzzz\CTG60.UAS
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General Information
Symbol
Zzzz\CTG60.UAS
Species
a. artificial
Name
FlyBase ID
FBal0283028
Feature type
allele
Associated gene
Zzzz\CTG
Associated Insertion(s)
Carried in Construct
P{UAS-CTG.60}
Also Known As
UAS-(CTG)60
Transgenic product class
trinucleotide_repeat_expansion
(Garcia-Lopez et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
trinucleotide_repeat_expansion
(Garcia-Lopez et al., 2008)
Mutagen
in vitro construct
(Garcia-Lopez et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-CTG.60}
Cytology
Description

UASt regulatory sequences drive expression of 60 uninterrupted CTG repeats.

(Garcia-Lopez et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Zzzz\CTG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Garcia-Lopez et al., 2008)
      DMPK:n.3_prime_UTR[60CUG]
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      DMPK, (CTG)n REPEAT EXPANSION, 3-PRIME UTR
      DMPK:n.3_prime_UTR[60CTG]
      Associated human disease model(s)
      External database links
      ClinVar: 5049
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Zzzz\CTG60.Scer\UAS under the control of Scer\GAL4GMR.PU does not result in any gross morphological defects of the eye.

      Expression of Zzzz\CTG60.Scer\UAS under the control of Scer\GAL4how-24B does not results in any significant defect in larval locomotion, as compared to controls.

      (Luu et al., 2016)

      Expression of Zzzz\CTG60.Scer\UAS under the control of Scer\GAL4GMR.PU does not result in obvious morphological disturbance in the eye.

      (Wong et al., 2014)

      Flies expressing Zzzz\CTG60.Scer\UAS under the control of Scer\GAL4Mhc.PW do not show flight defects and the indirect flight muscles appear normal and do not generate over time.

      Expression of Zzzz\CTG60.Scer\UAS under the control of Scer\GAL4GMR.PU does not appreciably affect eye morphology.

      Expression of Zzzz\CTG60.Scer\UAS under the control of Scer\GAL4sev.PU causes minor defects in external eye morphology, affecting only mechanosensory bristles.

      (Garcia-Lopez et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Zzzz\CTG60.Scer\UAS
      Zzzz\CTG60.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (5)