FB2024_03 , released June 25, 2024
Allele: Dmel\Eogtex10
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General Information
Symbol
Dmel\Eogtex10
Species
D. melanogaster
Name
FlyBase ID
FBal0285168
Feature type
allele
Associated gene
Dmel\Eogt
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Müller et al., 2013)
Progenitor genotype
P{GT1}EogtBG00673
(Müller et al., 2013)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a deletion of part of Eogt, which extends from -171 to +673 relative to the start codon.

(Müller et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes die at the second instar larval stage, remaining at this stage for up to 48 hours before dying. A few escapers reach the third larval instar.

      Homozygous clones in the adult thorax result in a vortex phenotype.

      Homozygous clones in the wing result in deformed wings with blisters.

      Expression of EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa results in wing blistering specifically within the posterior compartment. This phenotype has almost complete penetrance at 27[o]C, and is not seen at 22.5[o]C. Eogtex10/+ enhances the phenotype, so that wing blistering with a penetrance of up to 30% is seen at 22.5[o]C.

      (Müller et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Eogtex10 has lethal phenotype, suppressible by Hsap\EOGTTub.PM

      (Müller et al., 2013)
      NOT suppressed by
      Statement
      Reference

      Eogtex10 has lethal phenotype, non-suppressible by Mmus\Pomgnt2Tub.PM

      (Müller et al., 2013)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\EOGTTub.PM rescues the lethality of Eogtex10 homozygotes. The rescued animals have no visible mutant phenotype.

      Expression of Mmus\Gtdc2Tub.PM does not rescue the lethality of Eogtex10 homozygotes.

      (Müller et al., 2013)
      Complementation and Rescue Data
      Rescued by

      Eogtex10 is rescued by EogtUAS.cMa/Scer\GAL4Tub.PU

      (Müller et al., 2013)
      Not rescued by

      Eogtex10 is not rescued by EogtUAS.cMa/Scer\GAL4hs.PU

      (Müller et al., 2013)

      Eogtex10 is not rescued by EogtUAS.cMa/Scer\GAL4Act.PU

      (Müller et al., 2013)
      Comments

      Expression of EogtScer\UAS.cMa under the control of Scer\GAL4tub.PU, but not under the control of either Scer\GAL4hs.PU or Scer\GAL4Act.PU, rescues Eogtex10 homozygotes to adulthood.

      (Müller et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Eogtex10
      eogtex10
      (Müller et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)