FlyBase Allele Report: Mmus\Xbp1[UAS.cCTa]

General Information

Symbol

Mmus\Xbp1^UAS.cCTa

Species

M. musculus

Name

FlyBase ID

FBal0285874

Feature type

allele

Associated gene

Mmus\Xbp1

Associated Insertion(s)

Carried in Construct

P{UAS-mXBP1.WT}

Also Known As

UAS-mXbp1s

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Casas-Tinto et al., 2011)

Progenitor genotype

Carried in construct

P{UAS-mXBP1.WT}

Cytology

Description

UAS regulatory sequences drive expression of Mmus\Xbp1 sequences encoding the active (spliced) version of Mmus\Xbp1.

(Casas-Tinto et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mmus\Xbp1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease

modeled by Hsap\APP^2xAPP.SP.UAS

(Casas-Tinto et al., 2011)

ameliorates neurodegenerative disease

modeled by sws¹

(Sunderhaus et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Overexpression of Mmus\Xbp1^{Scer\UAS.cCTa} in the developing eye (under the control of Scer\GAL4^GMR.PF) does not perturb eye development.

(Casas-Tinto et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Mmus\Xbp1^UAS.cCTa, Scer\GAL4^Tub.PU is a suppressor | partially of lethal - all die during second instar larval stage phenotype of Marf^GD11094, Scer\GAL4^Tub.PU

(Debattisti et al., 2014)

Mmus\Xbp1^UAS.cCTa, Scer\GAL4^Mhc.PU is a suppressor of abnormal locomotor behavior | adult stage phenotype of Marf^GD11094, Scer\GAL4^Mhc.PU

(Debattisti et al., 2014)

Scer\GAL4^elav-C155/Mmus\Xbp1^UAS.cCTa is a suppressor of abnormal eye color phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

Phenotype Manifest In

Suppressor of

Statement

Reference

Mmus\Xbp1^UAS.cCTa, Scer\GAL4^Tub.PU is a suppressor of endoplasmic reticulum | larval stage phenotype of Marf^GD11094, Scer\GAL4^Tub.PU

(Debattisti et al., 2014)

Mmus\Xbp1^UAS.cCTa, Scer\GAL4^Mhc.PU is a suppressor of sarcoplasmic reticulum | larval stage phenotype of Marf^GD11094, Scer\GAL4^Mhc.PU

(Debattisti et al., 2014)

Mmus\Xbp1^UAS.cCTa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

Mmus\Xbp1^UAS.cCTa, Scer\GAL4^GMR.PF is a suppressor of retina phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

Mmus\Xbp1^UAS.cCTa, Scer\GAL4^GMR.PF is a suppressor of photoreceptor neuron phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

Mmus\Xbp1^UAS.cCTa, Scer\GAL4^GMR.PF is a suppressor of eye | progressive phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

NOT Suppressor of

Statement

Reference

Mmus\Xbp1^UAS.cCTa, Scer\GAL4^Tub.PU is a non-suppressor of mitochondrion | larval stage phenotype of Marf^GD11094, Scer\GAL4^Tub.PU

(Debattisti et al., 2014)

Mmus\Xbp1^UAS.cCTa, Scer\GAL4^Mhc.PU is a non-suppressor of mitochondrion | larval stage phenotype of Marf^GD11094, Scer\GAL4^Mhc.PU

(Debattisti et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Mmus\Xbp1^{Scer\UAS.cCTa} suppresses the impaired climbing ability of Scer\GAL4^Mhc.PU Marf^GD11094 flies.

(Debattisti et al., 2014)

Co-expression of Mmus\Xbp1^{Scer\UAS.cCTa} with Hsap\APP^{2xAPP.SP.Scer\UAS} (both under the control of Scer\GAL4^GMR.PF) results in bigger, better-organised eyes that lack necrotic spots. Additionally, retinae are thicker and photoreceptors and lenses are better differentiated.

Hsap\APP^{2xAPP.SP.Scer\UAS} flies co-expressing either Mmus\Xbp1^{Scer\UAS.cCTa} in the developing eye (under the control of Scer\GAL4^GMR.PF) show milder degenerative changes in the retina compared to flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS}, indicating Mmus\Xbp1 protects against the progressive degeneration of photoreceptors induced by Hsap\APP.

(Casas-Tinto et al., 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Mmus\Xbp1^{Scer\UAS.cCTa}

Mmus\Xbp1^UAS.cCTa

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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