FB2024_03 , released June 25, 2024
Allele: Dmel\plumΔ2
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General Information
Symbol
Dmel\plumΔ2
Species
D. melanogaster
Name
FlyBase ID
FBal0288229
Feature type
allele
Associated gene
Dmel\plum
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
FLPase
(Yu et al., 2013)
Progenitor genotype
P{XP}CG5455d09586
(Yu et al., 2013)
PBac{WH}plumf01589
(Yu et al., 2013)
Cytology
Description

Scer\FRT-mediated recombination between the two progenitor insertions have resulted in the deletion of genomic sequence including part of plum.

(Yu et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:26,461,413..26,477,368 [-]
Comment:

Deletion resulting from FLP-catalyzed recombination using the FRT-containing transposons P{XP}CG5455d09586 and PBac{WH}plumf01589.

(Yu et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The transverse nerve makes inappropriate connections at the neuromuscular junction in plumΔ2 larvae.

      (Yu et al., 2013)

      The frequency of improper, ectopic projections at the larval neuromuscular junction is increased compared to wild-type controls, with the majority of the ectopic connections being made by the transverse nerve.

      (Yu et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of EcRB1.Scer\UAS under the control of Scer\GAL4elav.PU partially rescues the formation of ectopic connections at the neuromuscular junction in plumΔ1/plumΔ2 larvae.

      (Yu et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      plumΔ2 is rescued by plumGFP,Tag:HA

      (Yu et al., 2013)

      plumΔ2 is rescued by Scer\GAL4elav.PU/plumUAS.Tag:HA

      (Yu et al., 2013)

      plumΔ2 is rescued by Scer\GAL4elav.PU/plumΔIg1-3.UAS.Tag:FLAG

      (Yu et al., 2013)

      plumΔ2 is rescued by Scer\GAL4elav.PU/plumΔCyt.UAS.Tag:FLAG

      (Yu et al., 2013)
      Not rescued by

      plumΔ2 is not rescued by Scer\GAL4Mef2.247/plumUAS.Tag:HA

      (Yu et al., 2013)

      plumΔ2 is not rescued by Scer\GAL4repo.PU/plumUAS.Tag:HA

      (Yu et al., 2013)

      plumΔ2 is not rescued by plumΔIg4.UAS.Tag:FLAG/Scer\GAL4elav.PU

      (Yu et al., 2013)
      Comments

      plumT:Avic\GFP,T:Ivir\HA1 completely rescues the formation of ectopic connections at the neuromuscular junction in plumΔ2 larvae.

      (Yu et al., 2013)

      Expression of plumScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4elav.PU (but not under the control of either Scer\GAL4Mef2.247 or Scer\GAL4repo.PU) rescues the formation of ectopic connections at the neuromuscular junction in plumΔ2 larvae.

      Expression of plumΔIg1-3.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4elav.PU rescues the formation of ectopic connections at the neuromuscular junction in plumΔ2 larvae.

      Expression of plumΔIg4.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4elav.PU fails to rescue the formation of ectopic connections at the neuromuscular junction in plumΔ2 larvae.

      Expression of plumΔCyt.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4elav.PU rescues the formation of ectopic connections at the neuromuscular junction in plumΔ2 larvae.

      (Yu et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      plumΔ2
      (Yu et al., 2013, Yu et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)