FB2024_03 , released June 25, 2024
Allele: Dmel\BigH1100
Open Close
General Information
Symbol
Dmel\BigH1100
Species
D. melanogaster
Name
FlyBase ID
FBal0290389
Feature type
allele
Associated gene
Dmel\BigH1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Pérez-Montero et al., 2013)
Mutagen
P-element activity
(Pérez-Montero et al., 2013)
Progenitor genotype
P{EP}BigH1G18579
(Pérez-Montero et al., 2013)
Cytology
Description

Imprecise excision of the progenitor insertion. The mutant allele carries multiple changes in the 5'UTR relative to the progenitor.

(Pérez-Montero et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
complex_substitution
3R:14,663,537..14,663,564 [+]
Comment:

Multiple nucleotide substitutions and indels in the region just upstream of the BigH1 ATG.

(Pérez-Montero et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos derived from a cross between heterozygous parents show a shorter nucleosome repeat length compared to wild-type control embryos.

      Homozygous embryos show highly asynchronous divisions and altered nuclei distribution during the blastoderm stage and show signs of intense DNA damage. The embryos show more than 92% lethality prior to the cellular blastoderm stage. No homozygous larvae are obtained.

      (Pérez-Montero et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      BigH1100 is partially rescued by Scer\GAL4nanos.PG/BigH1UAS.cPa

      (Pérez-Montero et al., 2013)
      Not rescued by

      BigH1100 is not rescued by Scer\GAL4nanos.PG/BigH1G18579

      (Pérez-Montero et al., 2013)
      Comments

      Expression of BigH1Scer\UAS.cPa under the control of Scer\GAL4nos.PG can significantly rescue the lethality of BigH1100 homozygotes: approximately 19.4% adult viability is seen. This rescue is only seen when BigH1Scer\UAS.cPa is supplied paternally.

      Expression of BigH1G18579 under the control of Scer\GAL4nos.PG (both provided maternally) does not rescue the lethality of BigH1100 homozygotes.

      (Pérez-Montero et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      BigH1100
      bigH1100
      (Pérez-Montero et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)