FB2024_03 , released June 25, 2024
Allele: Dmel\dpnUAS.cVa
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General Information
Symbol
Dmel\dpnUAS.cVa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Vaessin
FlyBase ID
FBal0290400
Feature type
allele
Associated gene
Dmel\dpn
Associated Insertion(s)
Carried in Construct
P{UAS-dpn.V}
Also Known As
UAS-dpn
Key Links
Transgenic product class
wild_type
(Babaoğlan et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Babaoğlan et al., 2013)
Mutagen
in vitro construct
(Babaoğlan et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-dpn.V}
Cytology
Description

UAS regulatory sequences drive expression of dpn.

(Babaoğlan et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dpn
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of dpnScer\UAS.cVa under the control of both Scer\GAL4insc-Mz1407 and Scer\GAL80ase.PZ results in a massive increase in the number of type II neuroblasts and numerous small non-ase-expressing immature intermediate neural progenitors (INPs) in third larval instar brains. In contrast to wild type, these ectopic neuroblast and INP cells are found in adult brains in the mutant animals.

      Type II neuroblast clones in larvae expressing dpnScer\UAS.cVa under the control of Scer\GAL4insc-Mz1407 are much larger and contain more neuroblasts and immature INPs than wild-type clones. The ratio of immature INPs to neuroblasts is increased from 2:1 to 8:1 in the mutant clones.

      Type I neuroblast clones in larvae expressing dpnScer\UAS.cVa under the control of either Scer\GAL4ase.neuro or Scer\GAL4insc-Mz1407 contain an increased number of neuroblasts and ganglion mother cells compared to control clones, with some persisting into adult brains.

      (Zhu et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      dpnScer\UAS.cVa
      dpnUAS.cVa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Vaessin
      Secondary FlyBase IDs
        References (3)