FB2024_03 , released June 25, 2024
Allele: Dmel\lig1
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General Information
Symbol
Dmel\lig1
Species
D. melanogaster
Name
FlyBase ID
FBal0295153
Feature type
allele
Associated gene
Dmel\lig
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Baumgartner et al., 2013)
Mutagen
ethyl methanesulfonate
(Baumgartner et al., 2013)
Progenitor genotype
Cytology
Description

A small deletion of 5 bp (nucleotides 3959163-3959167) and an insertion of an adenine at position 3959174 (release 5.45).

(Baumgartner et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:8,071,658..8,071,662 [+]
Comment:

5 bp deletion at 2R:3959163..3959167 in R5 coordinates.

(Baumgartner et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      lig1 mutant eyes, generated by eyFLP/FRT-mediated mitotic recombination, are bigger than controls.

      Mutants transheterozygous with ligPP1 or Df(2R)Exel7094 die in an early pupal stage forming long and slender pupae.

      All cell types differentiate are structured normally, without cell size defects, in lig1 mutant ommatidia within mosaic compound eyes.

      lig1 mutant eyes, generated by eyFLP/FRT-mediated mitotic recombination, generally show increased ommatidial number, but in some cases this is equal or even lower than in controls. (Ommatidial size is unaffected.) Mutants raised on food with reduced yeast content display eyes with a constant increase in ommatidial number, while mutants raised on increased yeast content show more pronounced variability in ommatidial number. This diet-dependent eye phenotype is not dependent on amino acid levels or developmental delay.

      (Baumgartner et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      lig1 mutant eyes over-expressing thEP3723 via eyFLP, Actin-Flp out-Gal4/FRT-mediated mitotic recombination, display increased ommatidia number compared to either single mutant condition.

      (Baumgartner et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference

      Animals with lig1 mutant eyes over-expressing BacA\p35Scer\UAS.cHa via eyFLP, Actin-Flp out-Gal4/FRT-mediated mitotic recombination, die as pharate adults except a few escapers that display massively overgrown eye structures.

      (Baumgartner et al., 2013)
      Complementation and Rescue Data
      Rescued by

      lig1 is rescued by lig+t12

      (Baumgartner et al., 2013)
      Not rescued by

      lig1 is not rescued by ligt12

      (Baumgartner et al., 2013)
      Comments

      lig+t12, but not ligt12, rescues the lethality and clonal overgrowth phenotype associated with lig1.

      (Baumgartner et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      lig1
      (Baumgartner et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)