Imprecise excision of the progenitor insertion, resulting in a 1174bp deletion that includes exon 1 of MED19.
Inferred location of 1174 bp deletion resulting from the imprecise excision of P{EPgy2}EY16159, which extends from the insertion into MED19, removing the first exon.
lethal (with Df(3L)BSC8)
visible (with MED19Ubi.PB)
Homozygotes die at the end of embryogenesis, without cuticular defects. Embryos derived from homozygous female germline clones undertake development, but abnormalities are visible by the pre-cellular blastoderm, resulting in extremely disorganised cellular embryos that die soon after.
Homozygous somatic clones are not recovered in the imaginal discs, indicating cell lethality, but they do survive if they are induced in a Minute background. Homozygous clones induced in a Minute background in the dorsal compartment of the haltere disc result in disorganisation and a reduction in number of the pedicellar sensillae.
MED191/MED192 pupae show a fully penetrant loss of anterior spiracles.
MED192 homozygotes carrying MED19Ubi.PB occasionally survive to adulthood. These escapers show loss of maxillary palps.
MED192/MED19[+] is a suppressor of visible | dominant phenotype of AntpNs-rvC3
MED192/MED19[+] is a suppressor of homeotic | dominant phenotype of AntpNs-rvC3
MED192/P{EPgy2}EY16159 is a suppressor of visible phenotype of UbxCbx-1
MED192/P{EPgy2}EY16159 is a suppressor of homeotic phenotype of UbxCbx-1
MED192/MED19[+] is a suppressor of antenna phenotype of AntpNs-rvC3
MED192/MED19[+] is a suppressor of leg | ectopic phenotype of AntpNs-rvC3
MED192/MED19[+] is a suppressor of maxillary palp | ectopic phenotype of Dfd1
MED192/P{EPgy2}EY16159 is a suppressor of wing blade posterior compartment phenotype of Ubx1:Cbx-1
MED192/P{EPgy2}EY16159 is a suppressor of haltere | ectopic phenotype of UbxCbx-1
MED192/+ partially suppresses the antenna-to-leg transformation seen in AntpNs-rvC3/+ flies, such that the double heterozygotes have antennal aristae.
The ectopic maxillary palp phenotype seen in Dfd1/+ flies is fully suppressed by MED192/+.
The transformation of posterior wing to hemi-haltere seen in UbxCbx-1 homozygotes is no longer seen if the flies are also carrying MED192/P{EPgy2}EY16159 and the cellular trichomes are reoriented along the long wing axis.
MED192/MED191 is rescued by Scer\GAL4arm.PU/MED19UAS.C-Venus
MED192/MED191 is rescued by MED19Ubi.PB
MED192 is rescued by Scer\GAL4en.PU/MED19UAS.C-Venus
MED192 is rescued by Scer\GAL4en.PU/MED19ΔHIM.UAS.C-Venus
MED192 is partially rescued by MED19Ubi.PB
MED192/MED191 is not rescued by MED19ΔHIM.UAS.C-Venus/Scer\GAL4arm.PU
Expression of MED19Scer\UAS.T:Avic\GFP-VC under the control of Scer\GAL4arm.PU rescues the lethality of MED191/MED192 animals.
Expression of MED19Scer\UAS.T:Avic\GFP-VC under the control of Scer\GAL4en.PU rescues the cell lethality of homozygous MED192 somatic clones.
Expression of MED19ΔHIM.Scer\UAS.T:Avic\GFP-VC under the control of Scer\GAL4arm.PU fails to rescue the lethality of MED191/MED192 animals.
Expression of MED19ΔHIM.Scer\UAS.T:Avic\GFP-VC under the control of Scer\GAL4en.PU rescues the cell lethality of homozygous MED192 somatic clones.