FB2024_03 , released June 25, 2024
Allele: Dmel\p53UAS.B.Tag:MYC
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General Information
Symbol
Dmel\p53UAS.B.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0302023
Feature type
allele
Associated gene
Dmel\p53
Associated Insertion(s)
Carried in Construct
P{UAS-Myc-p53.B}
PBac{UAS-Myc-p53.B}
Key Links
Transgenic product class
wild_type
(Zhang et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Zhang et al., 2014)
Mutagen
in vitro construct
(Zhang et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-Myc-p53.B}
PBac{UAS-Myc-p53.B}
Cytology
Description

UAS regulatory sequences drive expression of the B isoform of p53 tagged at the N-terminal end with 6xTag:MYC.

(Zhang et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
p53
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of p53Scer\UAS.B.T:Hsap\MYC under the control of Scer\GAL4GMR.PU results in a complete absence of eyes in all adults.

      Compared with controls, expression of Scer\GAL4GMR.PU>p53Scer\UAS.B.T:Hsap\MYC results in an increase in the number of apoptotic cells behind the morphogenetic furrow in eye discs.

      Expression of p53Scer\UAS.B.T:Hsap\MYC in the ovary under the control of Scer\GAL4hs.PU results in a significant increase in the number of apoptotic somatic follicle cells compared with controls.

      The number of apoptotic cells is greater in irradiated ovaries that express Scer\GAL4hs.PU>p53Scer\UAS.B.T:Hsap\MYC versus irradiation alone.

      (Zhang et al., 2015)

      Expression of p53Scer\UAS.B.T:Hsap\MYC under the control of Scer\GAL4fkh.PH induces a large amount of apoptosis in third instar larval wing disc, more than is seen when p53Scer\UAS.A.T:Hsap\MYC is expressed.

      Expression of p53Scer\UAS.B.T:Hsap\MYC under the control of Scer\GAL4hs.PU induces cell death in salivary glands.

      (Zhang et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      6XMyc-p53B
      (Chang et al., 2021)
      p53Scer\UAS.B.T:Hsap\MYC
      p53UAS.B.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (3)