Amino acid replacement: D164V.
A6325927T
D164V | PDZ-GEF-PA; D164V | PDZ-GEF-PB; D164V | PDZ-GEF-PC; D164V | PDZ-GEF-PD
D164V
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
Homozygotes show loss of photoreceptor cells: 40% of ommatidia lack an R7 cell and 10% of ommatidia lack at least one outer photoreceptor cell.
PDZ-GEFE-174/Df(2L)BSC5 flies show loss of photoreceptor cells: 54% of ommatidia lack an R7 cell and 11% of ommatidia lack at least one outer photoreceptor cell.
PDZ-GEF[+]/PDZ-GEFE-174 is an enhancer of visible phenotype of cnkCCT.hs.sev
PDZ-GEF[+]/PDZ-GEFE-174 is an enhancer of eye phenotype of cnkCCT.hs.sev
PDZ-GEF[+]/PDZ-GEFE-174 is an enhancer of eye photoreceptor cell phenotype of cnkCCT.hs.sev
PDZ-GEFE-174 dominantly enhances the rough eye phenotype seen in flies expressing cnkCCT.hs.sev. In addition, the double mutant flies show an increased loss of photoreceptor cells compared to cnkCCT.hs.sev single mutants.