FB2024_03 , released June 25, 2024
Allele: Dmel\dnr12-133
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General Information
Symbol
Dmel\dnr12-133
Species
D. melanogaster
Name
FlyBase ID
FBal0319744
Feature type
allele
Associated gene
Dmel\dnr1
Associated Insertion(s)
P{}dnr12-133
Carried in Construct
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Cao et al., 2013)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{}dnr12-133
    Cytology
    Description

    P insertion in the 5' UTR of dnr1.

    (Cao et al., 2013)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  neurodegenerative disease
        CEA
        (Cao et al., 2013)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        dnr12-133/dnr12-133 flies show age-dependent neurodegeneration (presence of vacuolar lesions in the brain at day 15 that are not seen in controls or at day 5 or 10, becoming more pronounced in size and frequency at day 25 and 35); dnr12-133/+ heterozygotes are similar to wild type. dnr12-133/Df(2R)X58-12 flies show age-dependent neurodegeneration (significant compared to controls at day 10 onwards). dnr12-133/dnr12-133 flies have a significantly reduced lifespan compared to wild type or heterozygotes at 29[o]C. dnr12-133/dnr12-133 fly brains do not show signs of elevated apoptosis (measured at 20 and 25 days old) compared to controls.

        (Cao et al., 2013)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Phenotype Manifest In
        Suppressed by
        Statement
        Reference

        dnr12-133 has adult brain | progressive phenotype, suppressible by RelE38/RelE20

        (Cao et al., 2013)

        dnr12-133 has adult brain | progressive phenotype, suppressible by RelE20/Df(3R)ED5331

        (Cao et al., 2013)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        RelE20/Df(3R)ED5331 or RelE20/RelE38 significantly suppresses neurodegeneration in dnr12-133/dnr12-133 flies (measured at 29[o]C at 25 days old).

        (Cao et al., 2013)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        dnr12-133/Df(2R)X58-12 is rescued by Scer\GAL4Act5C.PU/dnr1UAS.Tag:HA

        (Cao et al., 2013)
        Comments

        Expression of dnr1Scer\UAS.T:Ivir\HA1 driven by Scer\GAL4Act5C.PU significantly rescues neurodegeneration in dnr12-133/Df(2R)X58-12 flies.

        (Cao et al., 2013)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        dnr12-133
        (Cao et al., 2013)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)