FB2024_03 , released June 25, 2024
Allele: Dmel\Pepck1Δ84
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General Information
Symbol
Dmel\Pepck1Δ84
Species
D. melanogaster
Name
FlyBase ID
FBal0320773
Feature type
allele
Associated gene
Dmel\Pepck1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Bartok et al., 2015)
Mutagen
P-element activity
(Bartok et al., 2015)
Progenitor genotype
P{EPgy2}EY10042
(Bartok et al., 2015)
Cytology
Description

825bp deletion that removes the transcription start site, translation start codon and sequence encoding the N-terminal 108 amino acids of Pepck.

(Bartok et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:18,536,700..18,537,525 [+]
Comment:

Inferred boundaries of an 825 bp deletion resulting from the imprecise excision of P{EPgy2}EY10042 that extends into Pepck1@ from the insertion site and removes the first 108 amino acids.

(Bartok et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      PepckΔ84/Df(2R)ED3636 mutants display a modest but significant reduction in feeding, but no defects in pupal weight or developmental delay, as compared to controls.

      PepckΔ84/PepckΔ84 mutants die before eclosion.

      (Bartok et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Df(2R)ED3636/Pepck1Δ84 is a suppressor of partially lethal - majority die phenotype of bigmax1

      (Bartok et al., 2015)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      PepckΔ84/Df(2R)ED3636 rescues the lethality of bigmax1/bigmax1 mutants.

      (Bartok et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Pepck1Δ84
      PepckΔ84
      pepckΔ84
      (Bartok et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)