FB2024_03 , released June 25, 2024
Allele: Dmel\cavHipHop.GFP
Open Close
General Information
Symbol
Dmel\cavHipHop.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0320778
Feature type
allele
Associated gene
Dmel\cav
Associated Insertion(s)
Carried in Construct
M{HipHop-GFP.cav}
PBac{HipHop-GFP.cav}
Key Links
Transgenic product class
wild_type
(Dubruille and Loppin, 2015)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Dubruille and Loppin, 2015)
Mutagen
in vitro construct
(Dubruille and Loppin, 2015)
Progenitor genotype
Carried in construct
M{HipHop-GFP.cav}
PBac{HipHop-GFP.cav}
Cytology
Description

HipHop regulatory sequences drive expression of cav tagged at the N-terminal end with GFP.

(Dubruille and Loppin, 2015)
Allele components
Component
Use(s)
Regulatory region(s)
HipHop
Encoded product / tool
cav
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      cavHipHop.T:Avic\GFP/Y;cav1/Df(3R)Exel6198 adult males show only a slightly decreased fertility compared to controls.

      (Dubruille and Loppin, 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The slightly reduced fertility of cavHipHop.T:Avic\GFP/Y;cav1/Df(3R)Exel6198 adult (cav1 rescue) males is significantly enhanced by combination with Df(3R)ms(3)K81-2 and also by combination with HipHop1 albeit less strongly. The fertility of cavHipHop.T:Avic\GFP/Y;cav1,Df(3R)ms(3)K81-2/HipHop1,Df(3R)Exel6198 males is intermediate to that of cavHipHop.T:Avic\GFP/Y;cav1/Df(3R)Exel6198 males combined with either the Df(3R)ms(3)K81-2 or the HipHop1 allele alone.

      The slightly reduced fertility of cavHipHop.T:Avic\GFP/Y;cav1/Df(3R)Exel6198 adult (cav1 rescue) males is moderately enhanced by combination with verS147910.

      The slightly reduced fertility of cavHipHop.T:Avic\GFP/Y;cav1/Df(3R)Exel6198 adult (cav1 rescue) males is moderately improved by combination with moi1.

      The increased number of abnormal spermatid nuclei (showing chromatin bridges) characteristic for adult cavHipHop.T:Avic\GFP;cav1/Df(3R)Exel6198 males is strongly enhanced by combination with Df(3R)ms(3)K81-2 in homozygous or, to a lesser degree, in heterozygous state. Enhancement of the abnormal nuclear phenotype is also observed upon combination with single copy of HipHop1 as well as verS147910 but the phenotype is not aggravated further by combination with heterozygous moi1 allele.

      The fertility of ms(3)K81T:Avic\GFP/+;Df(3R)ms(3)K81-2/Df(3R)ms(3)K81-2 as well as cavHipHop.T:Avic\GFP/Y;cav1/+ adult males is normal, males of the combined genotype cavHipHop.T:Avic\GFP/Y;ms(3)K81T:Avic\GFP/+;cav1,Df(3R)ms(3)K81-2/Df(3R)ms(3)K81-2 display only slight decrease in fertility but this is dramatically enhanced by combination with Df(3R)Exel6198 - cavHipHop.T:Avic\GFP/Y;ms(3)K81T:Avic\GFP/+;cav1,Df(3R)ms(3)K81-2/Df(3R)Exel6198,Df(3R)ms(3)K81-2 males are almost completely sterile.

      (Dubruille and Loppin, 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      cavHipHop.GFP partially rescues cav1/Df(3R)Exel6198

      (Dubruille and Loppin, 2015)
      Comments

      The lethality of cav1/Df(3R)Exel6198 flies is rescued by combination with cavHipHop.T:Avic\GFP. The adult cavHipHop.T:Avic\GFP;cav1/Df(3R)Exel6198 males have normal-sized testes and their fertility is only slightly decreased compared to controls.

      (Dubruille and Loppin, 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      cavHipHop.GFP
      cavHipHop.T:Avic\GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)