FB2024_03 , released June 25, 2024
Allele: Dmel\HΔM3
Open Close
General Information
Symbol
Dmel\HΔM3
Species
D. melanogaster
Name
FlyBase ID
FBal0326746
Feature type
allele
Associated gene
Dmel\H
Associated Insertion(s)
TI{TI}HΔM3
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
cre recombinase
(Smylla et al., 2016)
Progenitor genotype
HΔM3.w+
(Smylla et al., 2016)
Associated Insertion(s)
TI{TI}HΔM3
Cytology
Description

The loxP cassette in HΔM3.w+ has been excised. The locus encodes H lacking introns and carrying a mutation in the third possible start codon (amino acid replacement M148V). As a consequence only the p120 protein isoform cannot be produced. A residual attR site is present in the 5'UTR and a single loxP site is present in the 3'UTR.

(Smylla et al., 2016)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult HΔM3 homozygous mutants do not display significant bristle defects with the number of aberrant bristles within the range observed in wild-type, no abnormalities in wing venation are seen either, but the wing size is significantly reduced compared to controls. However, when combined with the HattP allele, the transheterozygotes show very severe bristle defects (more than 30 affected).

      (Smylla et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      H[+]/HΔM3 is a suppressor of visible | adult stage phenotype of DeltaB2

      (Smylla et al., 2016)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      H[+]/HΔM3 is a suppressor of wing vein phenotype of DeltaB2

      (Smylla et al., 2016)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The wing notching phenotype of Df(1)N-54l9/+ heterozygotes is not significantly altered if they are also heterozygous for HΔM3.

      The vein thickening and vein deltas characteristic for HattP/+ adults is partially suppressible by combination with a single copy of HΔM3.

      (Smylla et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      HΔM3
      (Smylla et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)