FB2024_03 , released June 25, 2024
Allele: Dmel\mmyslm
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General Information
Symbol
Dmel\mmyslm
Species
D. melanogaster
Name
FlyBase ID
FBal0335679
Feature type
allele
Associated gene
Dmel\mmy
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Manavalan et al., 2017)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: ?75term.

    (Manavalan et al., 2017)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2L:6,471,442..6,471,442 [-]
    Nucleotide change:

    A6471442T

    Amino acid change:

    K75term | mmy-PD; K75term | mmy-PB; K112term | mmy-PA

    Reported amino acid change:

    ?75term

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Manavalan et al., 2017)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        mmyslm homozygous embryos exhibit fully penetrant defects in the longitudinal connective only after 13/14h post-fertilization, when they show narrower axon bundles of longitudinal connectives, thicker commissures, which are also closer to one another, severe axon guidance defects of posterior corner cell neurons' longitudinal tracks, namely the M track inappropriately crossing the midline, the I and L tracks collapsing onto one another,and significant decreases in the thickness of these tracks and in their distance to the midline, as compared to controls.

        (Manavalan et al., 2017)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT suppressed by
        Statement
        Reference

        mmyslm has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by Scer\GAL4elav.PU/robo1UAS.cKa

        (Manavalan et al., 2017)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The defects in axon medial tracts observed in late mmyslm homozygous embryos are not suppressed by the expression of robo1Scer\UAS.cKa under the control of Scer\GAL4elav.PU.

        (Manavalan et al., 2017)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        mmyslm is rescued by Scer\GAL4elav.PU/mmyUAS.cMa/Scer\GAL4sim.PU

        (Manavalan et al., 2017)
        Partially rescued by

        mmyslm is partially rescued by mmyUAS.cMa/Scer\GAL4sim.PU

        (Manavalan et al., 2017)
        Comments

        The severe axon guidance defects at the longitudinal connective of late mmyslm homozygous embryos are partially and fully rescued by the expression of mmyScer\UAS.cMa under the control of Scer\GAL4sim.PU alone and in combination with Scer\GAL4elav.PU, respectively.

        (Manavalan et al., 2017)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Identified as a background mutation associated with the Df(2L)fn7 chromosome in BDSC stock number 6067. The mmyslm mutation can be recombined away from the Deficiency.

        (Manavalan et al., 2017)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        mmyslm
        (Manavalan et al., 2017)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)