FlyBase Allele Report: Dmel\Xxylt[Δcds]

General Information

Symbol

Dmel\Xxylt^Δcds

Species

D. melanogaster

Name

FlyBase ID

FBal0343999

Feature type

allele

Associated gene

Dmel\Xxylt

Associated Insertion(s)

TI{y^wing2+}Xxylt^Δcds

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Pandey et al., 2018)

Mutagen

CRISPR/Cas9

(Pandey et al., 2018)

gene targeting by homologous recombination

(Pandey et al., 2018)

Progenitor genotype

Associated Insertion(s)

TI{y^wing2+}Xxylt^Δcds

Cytology

Description

Deletion of 87% of the Xxylt gene region, including the entire coding sequence. A TI{y^wing2+} cassette has been inserted in place of the deleted sequence.

(Pandey et al., 2018)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

2R:24,022,547..24,023,960 [+]

Comment:

Deletion of 87% of the Xxylt gene region, including the entire coding sequence. A TI{y^wing2+} cassette has been inserted in place of the deleted sequence. Deletion coordinates inferred by curator from primer sequences.

(Pandey et al., 2018)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Pandey et al., 2018)

viable

(Pandey et al., 2018)

Phenotype Manifest In

Detailed Description

Statement

Reference

Xxylt^Δcds homozygotes do not show wing vein loss or head bristles loss.

(Pandey et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Xxylt^Δcds/Xxylt^Δcds is a suppressor of abnormal size | dominant | adult stage | temperature conditional phenotype of N^55e11

(Pandey et al., 2018)

shams^Δ34/shams[+], Xxylt^Δcds/Xxylt^Δcds is a suppressor of abnormal size | dominant | adult stage | temperature conditional phenotype of N^55e11

(Pandey et al., 2018)

NOT Suppressor of

Statement

Reference

Xxylt[+]/Xxylt^Δcds is a non-suppressor of abnormal size | dominant | adult stage | temperature conditional phenotype of N^55e11

(Pandey et al., 2018)

Xxylt^gt-wt.Tag:V5, Xxylt^Δcds/Xxylt^Δcds is a non-suppressor of abnormal size | dominant | adult stage | temperature conditional phenotype of N^55e11

(Pandey et al., 2018)

Phenotype Manifest In

Suppressor of

Statement

Reference

Xxylt^Δcds/Xxylt^Δcds is a suppressor of wing vein | temperature conditional phenotype of N^55e11

(Pandey et al., 2018)

shams^Δ34/shams[+], Xxylt^Δcds/Xxylt^Δcds is a suppressor of wing margin | temperature conditional phenotype of N^55e11

(Pandey et al., 2018)

shams^Δ34/shams[+], Xxylt^Δcds/Xxylt^Δcds is a suppressor of wing vein | temperature conditional phenotype of N^55e11

(Pandey et al., 2018)

Xxylt^Δcds/Xxylt^Δcds is a suppressor of wing vein phenotype of Delta^9P

(Pandey et al., 2018)

Xxylt^Δcds/Xxylt^Δcds is a suppressor of wing margin | temperature conditional phenotype of N^55e11

(Pandey et al., 2018)

NOT Suppressor of

Statement

Reference

Xxylt[+]/Xxylt^Δcds is a non-suppressor of wing margin | temperature conditional phenotype of N^55e11

(Pandey et al., 2018)

Xxylt[+]/Xxylt^Δcds is a non-suppressor of wing vein | temperature conditional phenotype of N^55e11

(Pandey et al., 2018)

Xxylt^gt-wt.Tag:V5, Xxylt^Δcds/Xxylt^Δcds is a non-suppressor of wing margin | temperature conditional phenotype of N^55e11

(Pandey et al., 2018)

Xxylt^gt-wt.Tag:V5, Xxylt^Δcds/Xxylt^Δcds is a non-suppressor of wing vein | temperature conditional phenotype of N^55e11

(Pandey et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

The wing margin loss and wing vein thickening observed in N^55e11 hemizygous males are partially suppressed by Xxylt^Δcds homozygosity; suppression by the combination of Xxylt^Δcds homozygosity and shams^Δ34 heterozygosity is more efficient than by either single mutant.

(Pandey et al., 2018)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Xxylt^Δcds

(Pandey et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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