FB2024_03 , released June 25, 2024
Allele: Dmel\Regnase-1KO
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General Information
Symbol
Dmel\Regnase-1KO
Species
D. melanogaster
Name
FlyBase ID
FBal0352667
Feature type
allele
Associated gene
Dmel\Regnase-1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Zhu et al., 2019)
Mutagen
CRISPR/Cas9
(Zhu et al., 2019)
Progenitor genotype
Cytology
Description

5bp deletion within the coding sequence, producing an in-frame premature stop codon that is predicted to result in the production of a protein composed of the N-terminal 83 amino acid residues of the wild-type Regnase-1 protein plus an additional 42 frameshifted residues.

(Zhu et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:20,035,669..20,035,673 [-]
Comment:

A 5bp deletion causes a frameshift and leads to early translation termination after the addition of 42 novel amino acids.

Consequences_of_mutation:

frameshift

(Zhu et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Regnase-1KO
      regnase-1KO
      (Zhu et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)