FB2024_03 , released June 25, 2024
Allele: Dmel\CG42724UY5237
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General Information
Symbol
Dmel\CG42724UY5237
Species
D. melanogaster
Name
FlyBase ID
FBal0355625
Feature type
allele
Associated gene
Dmel\CG42724
Associated Insertion(s)
P{Mae-UAS.6.11}CG42724UY5237
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Pons et al., 2018)
Progenitor genotype
Associated Insertion(s)
P{Mae-UAS.6.11}CG42724UY5237
Cytology
Description

A P{Mae-UAS.6.11} transposon inserted 170 bp upstream of the CG42724 gene, able to drive transcription of that gene in a GAL4-dependent manner.

(Pons et al., 2018)
Allele components
Component
Use(s)
Inserted element
P{Mae-UAS.6.11}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  amyotrophic lateral sclerosis type 10
      modeled by Hsap\TARDBPUAS.TDPBR
      (Pons et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of CG42724UY5237 induces a rough eye phenotype if driven by two copies of Scer\GAL4GMR.PU, but not by one copy only.

      (Pons et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Coexpression of CG42724UY5237 and Hsap\TARDBPUAS.TDPBR under the control of Scer\GAL4GMR.PU results in no eye phenotype with only one copy for each transgene and driver.

      Coexpression of Hsap\TARDBPUAS.TDPBR / Hsap\TARDBPUAS.TDPBR enhances the rough eye phenotype induced by expression of CG42724UY5237 under the control of Scer\GAL4GMR.PU / Scer\GAL4GMR.PU.

      (Pons et al., 2018)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      CG42724UY5237
      Name Synonyms
      Secondary FlyBase IDs
        References (1)