FB2024_03 , released June 25, 2024
Allele: Dmel\Hat1Δ57
Open Close
General Information
Symbol
Dmel\Hat1Δ57
Species
D. melanogaster
Name
FlyBase ID
FBal0356991
Feature type
allele
Associated gene
Dmel\Hat1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Varga et al., 2019)
Mutagen
Delta2-3 transposase
(Varga et al., 2019)
Progenitor genotype
P{EPgy2}Hat1EY21697
(Varga et al., 2019)
Cytology
Description

1409bp deletion (coordinates 3R:5787709..5789127 ) that removes the downstream Hat1-RA promoter, all splice sites and 80% of the Hat1 coding sequence (the deletion removes the acetyltransferase domain, resulting in a catalytically null allele). Generated by imprecise excision of P{EPgy2}Hat1EY21697.

(Varga et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:5,787,709..5,789,127 [-]
Comment:

A 1409bp deletion resulting from the imprecise excision of P{EPgy2}Hat1EY21697 that removes the downstream Hat1-RA promoter and 80% of the Hat1 coding sequence.

(Varga et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Huntington's disease
      modeled by Hsap\HTT90.Q120.UAS
      (Varga et al., 2019)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hat1Δ57 homozygotes do not show defects in motor activity, sleep activity, heat resistance or female fecundity.

      (Varga et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Hat1[+]/Hat1Δ57 is a suppressor | partially of decreased cell number | adult stage phenotype of Hsap\HTT90.Q120.UAS, Scer\GAL4elav.PU

      (Varga et al., 2019)
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hat1Δ57
      (Varga et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)