FlyBase Allele Report: Dmel\ft[Q805X]

General Information

Symbol

Dmel\ft^Q805X

Species

D. melanogaster

Name

FlyBase ID

FBal0357235

Feature type

allele

Associated gene

Dmel\ft

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Domingos et al., 2019)

Mutagen

ethyl methanesulfonate

(Domingos et al., 2019)

Progenitor genotype

Cytology

Description

A number of mutations have been found at the ft locus relative to the sequenced strain, including a premature stop codon at position 805.

(Domingos et al., 2019)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:4,215,428..4,215,428 [-]

Nucleotide change:

C4215428T

Amino acid change:

Q805term | ft-PA

Reported amino acid change:

Q805term

Comment:

19 missense variants were identified in the ft locus in strain in addition to this nonsense mutation. Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Domingos et al., 2019)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity | somatic clone

(Domingos et al., 2019)

abnormal size | adult stage | somatic clone

(Domingos et al., 2019)

increased cell death | larval stage | somatic clone

(Domingos et al., 2019)

Phenotype Manifest In

eye | somatic clone

(Domingos et al., 2019)

eye disc | somatic clone

(Domingos et al., 2019)

ommatidium | somatic clone

(Domingos et al., 2019)

Detailed Description

Statement

Reference

ft^Q805X clones generated in the larval eye disc lead to frequent ommatidial rotation phenotypes - planar cell polarity defects.

In eyes bearing ft⁸ clones, the clones are larger than control tissue, suggesting they have some competitive advantage; clonal regions in the eye disc show induction of apoptosis.

(Domingos et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

ft^Q805X, numb¹⁵ has abnormal planar polarity | somatic clone phenotype, suppressible | partially by Scer\GAL4^hs.2sev/numb^UAS.cWa

(Domingos et al., 2019)

Other

Statement

Reference

ft⁸/ft^Q805X, numb¹⁵ has abnormal cell polarity | adult stage phenotype

(Domingos et al., 2019)

ft^Q805X, numb¹⁵ has abnormal planar polarity | somatic clone | adult stage phenotype

(Domingos et al., 2019)

ft^Q805X, numb¹⁵ has abnormal planar polarity | somatic clone | larval stage phenotype

(Domingos et al., 2019)

Phenotype Manifest In

Suppressed by

Statement

Reference

ft^Q805X, numb¹⁵ has ommatidium | somatic clone phenotype, suppressible | partially by Scer\GAL4^hs.2sev/numb^UAS.cWa

(Domingos et al., 2019)

Other

Statement

Reference

ft⁸/ft^Q805X, numb¹⁵ has eye phenotype

(Domingos et al., 2019)

ft⁸/ft^Q805X, numb¹⁵ has posterior crossvein phenotype

(Domingos et al., 2019)

ft^Q805X, numb¹⁵ has ommatidium | somatic clone | larval stage phenotype

(Domingos et al., 2019)

ft^Q805X, numb¹⁵ has ommatidium | somatic clone | adult stage phenotype

(Domingos et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

numb¹⁵, ft^Q805X double mutant clones generated in the larval eye disc lead to frequent ommatidial rotation phenotypes - planar cell polarity defects - both in the larva and in adults.

The few ft^Q805X/ft⁸, numb¹⁵/+ adult escapers show medial cross-vein defect (Fig. 6B) and PCP defects in the eye.

(Domingos et al., 2019)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

ft^Q805X has been identified as a second-site mutation on the numb¹⁵ chromosome.

(Domingos et al., 2019)

Separable from: numb¹⁵.

(Domingos et al., 2019)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

fat^Q805*

(Domingos et al., 2019)

ft^Q805X

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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