FB2024_03 , released June 25, 2024
Allele: Dmel\Tsf1JP94
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General Information
Symbol
Dmel\Tsf1JP94
Species
D. melanogaster
Name
FlyBase ID
FBal0359953
Feature type
allele
Associated gene
Dmel\Tsf1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Iatsenko et al., 2020)
Mutagen
CRISPR/Cas9
(Iatsenko et al., 2020)
Progenitor genotype
Cytology
Description

Tsf1 mutant contains two nucleotide substitutions and a single nucleotide deletion, which leads to a frameshift with a premature stop codon at position 19.

(Iatsenko et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
complex_substitution
X:18,387,963..18,387,966 [+]
Inserted_sequence:

CAC

Comment:

Four bases (TAAG) are replaced with three bases (CAC) in the mutant resulting in af frameshift at amino acid 6 and translation termination after the addition of 14 novel amino acids.

(Iatsenko et al., 2020)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Tsf1JP94 adults exhibit an increased susceptibility to systemic infection with Cunninghamella bertholletiae, Rhizopus oryzae, Pseudomonas entomophila or Pseudomonas aeruginosa (PA14 (wild type, pchE or pvdP) or PAO1 (wild type or tonB1)).

      Tsf1JP94 adults exhibit an increased susceptibility to oral infection with P. entomophila or P. aeruginosa (PA14 (wild type, pchE or pvdP)) .

      Tsf1JP94 adults exhibit higher loads of P. aeruginosa and P. entomophila.

      (Iatsenko et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Tsf1JP94
      (Iatsenko et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)