FB2024_03 , released June 25, 2024
Allele: Hsap\RELAAD.Hsp70
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General Information
Symbol
Hsap\RELAAD.Hsp70
Species
H. sapiens
Name
FlyBase ID
FBal0361185
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

A heat responsive Hsp70 promoter (-242 to 0 relative to the transcription start site) regulates expression of the p65(AD)::Zip+ hemidriver.

Allele components
Component
Use(s)
Regulatory region(s)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Wing pouch ablation by the expression of rpr13xlexAop.cHa under the control of Ecol\lexADBD.R85E08 Hsap\RELAAD.Hsp70 during early third instar larval stage (induced by heat-shock) results in mostly wild-type or nicked wing blades; ablation during late third instar larval stage leads to mostly fully-notched or ablated wing blades. Similar ablation using egr13xlexAop.cHa instead of rpr13xlexAop.cHa leads to milder phenotypes.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
NOT Enhanced by
Suppressed by
Statement
Reference
NOT suppressed by
Phenotype Manifest In
Enhanced by
Statement
Reference
NOT Enhanced by
Statement
Reference
Suppressed by
NOT suppressed by
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Hsap\RELAAD.Hsp70
Name Synonyms
Secondary FlyBase IDs
    References (2)