FB2024_03 , released June 25, 2024
Allele: Dmel\mvros
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General Information
Symbol
Dmel\mvros
Species
D. melanogaster
Name
rosario
FlyBase ID
FBal0367419
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Embryos from mvros/Df(3L)R-G7 mothers show enlarged yolk granules. A small fraction shows aberrant mitotic spindles of different sizes associated with varying amounts of DNA, abnormal chromosome segregation and multiple centrosomes often in chains; the majority reaches the syncytial blastoderm stage but exhibit localized MTOC inactivation and loss of contact between nuclei and centrosomes at the cortex, leading nuclei to sink into the interior of the embryo (nuclear fallout); in live imaging, cortical migration of nuclei is followed by an abrupt flow of cytoplasm from within the embryo toward the surface, displacing the cortical nuclei toward the embryo's poles and leading to the surfacing of yolk nuclei, which normally get left behind in the embryo's interior.

    Stage 4 embryos from mvros/mv1 mothers show multiple centrosomes often in chains

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Symbol Synonym
    Name Synonyms
    rosario
    Secondary FlyBase IDs
      References (2)