rosario
a counterpart of mammalian LYST - suppresses vesicle fusion events with lipid droplets during the formation of yolk granules, the lysosome-related organelles of the syncytial embryo - opposes Rab5, which promotes fusion - localizes at spindle poles and co-immunoprecipitates with the microtubule-associated protein Minispindles - suggests a role for endosomal trafficking in the recruitment or maintenance of pericentriolar material components at centrosomes
Please see the JBrowse view of Dmel\mv for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
There is only one protein coding transcript and one polypeptide associated with this gene
Interacts with Rab5; the interaction is independent of GDP or GTP (PubMed:33725482). Interacts with msps (PubMed:33725482).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mv using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\mv in JBrowseProbably maps near tip of 3L.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
New stable cell line derived from S2-unspecified : DMEL cells expressing GFP-tagged mv under the contol of the MT promoter were created.
mv is required for a late step in autophagosome maturation.
Early stages of phagocytosis proceed normally in mv mutant hemocytes, but late phagosomes are enlarged compared to wild type.
Identified in an RNAi screen for host factors that alter infection of SL2 cells by L.monocytogenes.
Mutant syncytial embryos die showing strings of free centrosomes. The first detectable mitotic defect is the formation of spindles with paired centrosomes at each pole. As the embryos develop the centrosomes appear to remain clustered. Older embryos can have bipolar spindles with astral microtubules nucleated by as many as 12 centrosomes per pole.
Female sterile mutations in ros lead to long bead-like arrays of centrosomes at the spindle poles.
Source for merge of: CG11814 CG5691
Source for merge of: mv CG42863
Source for merge of: mv ros
Annotations CG11814 and CG5691 merged as CG42863 in release 5.30 of the genome annotation.
