FB2024_03 , released June 25, 2024
Allele: Hsap\EWSR1::HsapFLI11FS.UAS
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General Information
Symbol
Hsap\EWSR1::Hsap\FLI11FS.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0387934
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UASt regulatory sequences drive expression of a fusion protein composed of Hsap\EWSR1 amino acids 1-265 fused to sequence that originally encoded Hsap\FLI1 amino acids 242-452, but the Hsap\FLI1 sequence contains a 17 nucleotide deletion that results in the loss of 6 amino acids and a frameshift, thus only amino acids 242-383 of Hsap\FLI1 are present in the fusion protein, followed by a new 64 amino acid sequence.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
model of  Ewing sarcoma
is ameliorated by morHMS01267
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Hsap\EWSR1::Hsap\FLI11FS.UAS
Name Synonyms
Secondary FlyBase IDs
    References (1)