Gene Group: GLYCOSIDE HYDROLASES

General Information

Name

GLYCOSIDE HYDROLASES

Species

D. melanogaster

Symbol

FlyBase ID

FBgg0000832

Date last reviewed

2020-03-12

Number of members

Description

Glycoside hydrolases (GH) are a large group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. (Adapted from FBrf0232268).

Notes on Group

Source Material

The GLYCOSIDE HYDROLASES Gene Group has been compiled using the following publication(s): Zhang et al., 2024, Fontana et al., 2023, Feller et al., 2021, Behr and Riedel, 2020, Inomata et al., 2019, Claisse et al., 2016, Maor et al., 2016, Pesch et al., 2016, Yoshida et al., 2016, Jang et al., 2015, Rosenbaum et al., 2014, Lombard et al., 2013, Maor et al., 2013, Nemčovičová et al., 2013, Mortimer et al., 2012, Gabriško and Janeček, 2011, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Cattaneo et al., 2006, Leonard et al., 2006, Li et al., 2005, Zhu et al., 2004, Regel et al., 1998, Da Lage et al., 1996, Hultmark, 1996, Daffre et al., 1994, and Fuerst et al., 1987 .

Key Gene Ontology (GO) terms

Molecular Function

hydrolase activity, acting on glycosyl bonds

Biological Process

Cellular Component

Enzymatic activity

Enzyme name (EC)

3.2.-.-

Related Gene Groups

Parent group(s)

HYDROLASES

Component group(s)

N-GLYCOSYL HYDROLASES

O-GLYCOSYL HYDROLASES

Members (98)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

ALPHA,ALPHA-TREHALASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG6262

(Lombard et al., 2013)

Treh

Trehalase

TRE

(Yoshida et al., 2016, Lombard et al., 2013)

ALPHA-GALACTOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5731

(Lombard et al., 2013)

CG7997

(Lombard et al., 2013)

ALPHA-GLUCOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Agl

Glycogen debranching enzyme

(FlyBase, 2017-)

GCS2α

Glucosidase 2 α subunit

BcDNA:GH04962, α-glucosidase, clot#312

(FlyBase, 2017-)

Mal-A1

Maltase A1

LvpH, H, mal_A1, Larval visceral protein H

(Inomata et al., 2019, FlyBase, 2017-, Lombard et al., 2013, Gabriško and Janeček, 2011)

Mal-A2

Maltase A2

LvpD, mal_A2, D

(Inomata et al., 2019, FlyBase, 2017-, Lombard et al., 2013, Gabriško and Janeček, 2011)

Mal-A3

Maltase A3

LvpL, L, mal_A3

(Inomata et al., 2019, FlyBase, 2017-, Lombard et al., 2013, Gabriško and Janeček, 2011)

Mal-A4

Maltase A4

mal_A4

(Inomata et al., 2019, FlyBase, 2017-, Lombard et al., 2013, Gabriško and Janeček, 2011)

Mal-A5

Maltase A5

mal_A5

(Inomata et al., 2019, FlyBase, 2017-, Lombard et al., 2013, Gabriško and Janeček, 2011)

Mal-A6

Maltase A6

mal_A6

(Inomata et al., 2019, FlyBase, 2017-, Lombard et al., 2013, Gabriško and Janeček, 2011)

Mal-A7

Maltase A7

mal_A7

(Inomata et al., 2019, FlyBase, 2017-, Lombard et al., 2013, Gabriško and Janeček, 2011)

Mal-A8

Maltase A8

mal_A8

(Inomata et al., 2019, FlyBase, 2017-, Lombard et al., 2013, Gabriško and Janeček, 2011)

Mal-B1

Maltase B1

mal_B1

(Inomata et al., 2019, FlyBase, 2017-, Lombard et al., 2013, Gabriško and Janeček, 2011)

Mal-B2

Maltase B2

mal_B2

(Inomata et al., 2019, FlyBase, 2017-, Lombard et al., 2013, Gabriško and Janeček, 2011)

AMYLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Amy-d

Amylase distal

Amy, Amylase, α-amylase, alpha-amylase distal, AmyB

(FlyBase, 2017-, Lombard et al., 2013, Da Lage et al., 1996)

Amy-p

Amylase proximal

Amy, α-amylase, Amylase, alpha-amylase proximal, AmyA

(Feller et al., 2021, FlyBase, 2017-, Claisse et al., 2016, Lombard et al., 2013, Da Lage et al., 1996)

Amyrel

Amylase related

(Feller et al., 2021, FlyBase, 2017-, Claisse et al., 2016, Lombard et al., 2013)

BETA-GALACTOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Ect3

Ectoderm-expressed 3

anon-87Ag

(Lombard et al., 2013)

Gal

β galactosidase

β-gal

(Lombard et al., 2013, Fuerst et al., 1987)

BETA-GLUCOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG9701

(FlyBase, 2017-, Lombard et al., 2013)

CG33090

BG:DS01068.2

(FlyBase, 2017-)

BETA-GLUCURONIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

βGlu

β glucuronidase

Glu

(FlyBase, 2017-, Lombard et al., 2013)

CG15117

(FlyBase, 2017-, Lombard et al., 2013)

BETA-MANNOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

β-Man

β-Mannosidase

(FlyBase, 2017-, Rosenbaum et al., 2014, Lombard et al., 2013)

BETA-N-ACETYLHEXOSAMINIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG7985

(Lombard et al., 2013)

fdl

fused lobes

β-N-acetyl-D-glucosaminidase, l(2)k17040, β-N-acetylglucosaminidase, GlcNAc'ase

(Lombard et al., 2013, Cattaneo et al., 2006, Leonard et al., 2006)

Hexo1

Hexosaminidase 1

β-N-acetyl-D-hexosaminidase, GlcNAc'ase

(Lombard et al., 2013, Cattaneo et al., 2006, Leonard et al., 2006)

Hexo2

Hexosaminidase 2

β-N-acetyl-D-hexosaminidase, GlcNAc'ase, β-N-acetyl-D-glucosaminidase

(Lombard et al., 2013, Cattaneo et al., 2006, Leonard et al., 2006)

CHITINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Cht2

Chitinase 2

(Behr and Riedel, 2020, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Cht4

Chitinase 4

DmCHT4

(Behr and Riedel, 2020, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Cht5

Chitinase 5

DmCHT5

(Behr and Riedel, 2020, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Cht6

Chitinase 6

(Behr and Riedel, 2020, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Cht7

Chitinase 7

(Behr and Riedel, 2020, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Cht8

Chitinase 8

(Behr and Riedel, 2020, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Cht9

Chitinase 9

(Behr and Riedel, 2020, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Cht10

Chitinase 10

Cht3, chitinase-3, Cht1, Chitinase 3, DmCHT10

(Behr and Riedel, 2020, Pesch et al., 2016, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Cht11

Chitinase 11

(Behr and Riedel, 2020, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Cht12

Chitinase 12

(Behr and Riedel, 2020, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

DNA N-GLYCOSYLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Nthl1

Nth-like DNA glycosylase 1

(FlyBase, 2017-)

Ogg1

8-oxoguanine DNA glycosylase

(FlyBase, 2017-)

RpS3

Ribosomal protein S3

M(3)95A, M(3)w, S3, M(3R)w, Minute

(FlyBase, 2017-)

Smug

Single-strand-selective monofunctional uracil-DNA glycosylase

SMUG1

(FlyBase, 2017-)

Tdg

Thymine DNA glycosylase

Thd1, MUG, G/T-mismatch-specific-thymine-DNA-glycosylase

(FlyBase, 2017-)

ENDO-ALPHA MANNOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG14015

(FlyBase, 2017-, Lombard et al., 2013)

ENDOPLASMIC RETICULUM CLASS I ALPHA-MANNOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

α-Man-Ib

α-Mannosidase class I b

(Lombard et al., 2013, Nemčovičová et al., 2013, Mortimer et al., 2012)

ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Edem1

ER degradation enhancer, mannosidase alpha-like 1

EG:86E4.2

(Jang et al., 2015, Rosenbaum et al., 2014, Lombard et al., 2013)

Edem2

ER degradation enhancer, mannosidase alpha-like 2

(Jang et al., 2015, Rosenbaum et al., 2014, Lombard et al., 2013)

GLUCOSYLCERAMIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG33090

BG:DS01068.2

(FlyBase, 2017-)

Gba1a

Glucocerebrosidase 1a

dGBA1a

(Maor et al., 2016, Lombard et al., 2013, Maor et al., 2013)

Gba1b

Glucocerebrosidase 1b

dGBA1b

(Maor et al., 2016, Lombard et al., 2013, Maor et al., 2013)

GOLGI CLASS I ALPHA-MANNOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

α-Man-Ia

α-Mannosidase class I a

alpha-Man-I, mas-1, α-Man-I, mas1, alpha-mannosidase

(Lombard et al., 2013, Nemčovičová et al., 2013, Mortimer et al., 2012)

α-Man-Ic

α-Mannosidase class I c

(Lombard et al., 2013, Nemčovičová et al., 2013, Mortimer et al., 2012)

GOLGI CLASS II ALPHA-MANNOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

α-Man-IIa

α-Mannosidase class II a

dGMII, α-Man-II, GMII, alpha-Man-II, Golgi α-mannosidase II

(Rosenbaum et al., 2014, Lombard et al., 2013, Nemčovičová et al., 2013)

α-Man-IIb

α-Mannosidase class II b

α-mannosidase-IIb, ManII, alpha-mannosidase, ManIIb, Man'ase

(Rosenbaum et al., 2014, Lombard et al., 2013, Nemčovičová et al., 2013)

LYSOSOMAL CLASS II ALPHA-MANNOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

LManI

Lysosomal α-mannosidase I

(Rosenbaum et al., 2014, Lombard et al., 2013, Nemčovičová et al., 2013)

LManII

Lysosomal α-mannosidase II

LM408, BcDNA:GH02419, lysosomal α-mannosidase, dLM

(Rosenbaum et al., 2014, Lombard et al., 2013, Nemčovičová et al., 2013)

LManIII

Lysosomal α-mannosidase III

(Rosenbaum et al., 2014, Lombard et al., 2013, Nemčovičová et al., 2013)

LManIV

Lysosomal α-mannosidase IV

(Rosenbaum et al., 2014, Lombard et al., 2013, Nemčovičová et al., 2013)

LManV

Lysosomal α-mannosidase V

(Rosenbaum et al., 2014, Lombard et al., 2013, Nemčovičová et al., 2013)

LManVI

Lysosomal α-mannosidase VI

(Rosenbaum et al., 2014, Lombard et al., 2013, Nemčovičová et al., 2013)

LYSOZYMES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG6421

EG:EG0003.8

(Lombard et al., 2013)

CG6426

n(2)k04810

(Lombard et al., 2013)

CG6429

(Lombard et al., 2013)

CG6435

(FlyBase, 2017-)

CG7798

(Lombard et al., 2013, Li et al., 2005)

CG8492

(Lombard et al., 2013)

CG11159

(Lombard et al., 2013, Li et al., 2005)

CG14823

(FlyBase, 2017-)

CG16756

(Lombard et al., 2013, Li et al., 2005)

CG16799

(Lombard et al., 2013, Li et al., 2005)

CG30062

(Lombard et al., 2013)

LysB

Lysozyme B

(Lombard et al., 2013, Li et al., 2005, Regel et al., 1998, Hultmark, 1996, Daffre et al., 1994)

LysD

Lysozyme D

(Lombard et al., 2013, Li et al., 2005, Regel et al., 1998, Hultmark, 1996, Daffre et al., 1994)

LysE

Lysozyme E

(Lombard et al., 2013, Li et al., 2005, Regel et al., 1998, Hultmark, 1996, Daffre et al., 1994)

LysP

Lysozyme P

(Lombard et al., 2013, Li et al., 2005, Regel et al., 1998, Hultmark, 1996, Daffre et al., 1994)

LysS

Lysozyme S

(Lombard et al., 2013, Li et al., 2005, Regel et al., 1998, Hultmark, 1996, Daffre et al., 1994)

LysX

Lysozyme X

(Lombard et al., 2013, Li et al., 2005, Regel et al., 1998, Hultmark, 1996, Daffre et al., 1994)

NAD+ NUCLEOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Sarm

Sterile alpha and Armadillo motif

Ect4, dsarm, SARM1, Edis, Ectoderm-expressed 4

(FlyBase, 2017-)

PROTEIN ADP-RIBOSYL HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG2909

(Zhang et al., 2024)

CG3568

(Zhang et al., 2024)

Parg

Poly(ADP-ribose) glycohydrolase

(Fontana et al., 2023, FlyBase, 2017-)

Targ1

Terminal ADP-ribose protein glycohydrolase 1

(Fontana et al., 2023, FlyBase, 2017-)

Targ2

Terminal ADP-ribose protein glycohydrolase 2

(Fontana et al., 2023, FlyBase, 2017-)

Targ3

Terminal ADP-ribose protein glycohydrolase 3

(Fontana et al., 2023, FlyBase, 2017-)

RIBONUCLEOSIDE HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5418

(FlyBase, 2017-)

CG11158

(FlyBase, 2017-)

CG12177

(FlyBase, 2017-)

UNCLASSIFIED GLUCOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG16965

(FlyBase, 2017-, Lombard et al., 2013)

GCS1

Glucosidase 1

(FlyBase, 2017-, Lombard et al., 2013)

UNCLASSIFIED O-GLYCOSYL HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Agbe

1,4-Alpha-glucan branching enzyme

(FlyBase, 2017-)

CG33080

(FlyBase, 2017-)

ENGase

Endo-beta-N-acetylglucosaminidase

(FlyBase, 2017-, Lombard et al., 2013)

Fuca

α-L-fucosidase

(FlyBase, 2017-)

Idua

alpha-L-iduronidase

(FlyBase, 2017-, Lombard et al., 2013)

Naglu

N-acetyl-alpha-glucosaminidase

ESTS:172F5T

(FlyBase, 2017-, Lombard et al., 2013)

Oga

O-GlcNAcase

GlcNAcase

(FlyBase, 2017-, Lombard et al., 2013)

Parg

Poly(ADP-ribose) glycohydrolase

(FlyBase, 2017-)

tobi

target of brain insulin

(FlyBase, 2017-)

External Data

Equivalent Group(s)

Human Glycoside hydrolases (HGNC)

Other resource(s)

Synonyms and Secondary IDs

Synonym(s)

GLYCOSIDE HYDROLASES

Secondary FlyBase ID(s)

References (30)

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