β-N-acetylglucosaminidase, β-N-acetyl-D-glucosaminidase, l(2)k17040, GlcNAc'ase
Please see the JBrowse view of Dmel\fdl for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.49
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.57
Stop-codon suppression (UGA) postulated; FBrf0234051.
Gene model reviewed during 6.25
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fdl using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\fdl in JBrowse2-67
2-68.6
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of fdl CG8824 was sequence comparison ( date:020710 ).
FlyBase curator comment: The substrate specificities for the Hexosaminidase I ('NaDg' in FlyBase) and Hexosaminidase II ('NaDh' in FlyBase) enzymes characterized by Sommer and Spindler 1991 (FBrf0053181) match those of the HEX1 and HEX2 beta-hexosaminidase dimers, respectively, described by Cattaneo et al 2002 (FBrf0151346). A subsequent paper, Cattaneo et al 2006 (FBrf0193998), shows that HEX1 (aka HEXA) is a heterodimer comprising the products of fdl and Hexo2, while HEX2 (aka HEXB) is a dimer comprising the products of Hexo1 and Hexo2. Therefore, it appears the original 'Hexosaminidase I (NaDg)' defined in FBrf0053181 corresponds to both fdl and Hexo2, whereas Hexosaminidase II (NaDh) corresponds to both Hexo1 and Hexo2.
Source for identity of: fdl CG8824
The name "fused lobes" refers to the mushroom body phenotype seen in mutants.